Evidence map›Paper›PMID 33194001›Full record

Trial reportOxidative medicine and cellular longevity2020

Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study.

Giusy Tiseo, Elena Cavarretta, Arianna Forniti, Cristina Nocella, Sebastiano Sciarretta, Ornella Spagnolello, Enrico Baldini, Mariangela Peruzzi, Giuliano Bertazzoni, Francesco Menichetti and 6 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Giusy TiseoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Elena CavarrettaMediterranea Cardiocentro, Napoli, Italy.ORCID https://orcid.org/0000-0003-0221-6000
Arianna FornitiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Cristina NocellaDepartment of Internal Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Sebastiano SciarrettaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Ornella SpagnolelloDepartment of Angio-Cardio-Neurology, IRCCS NeuroMed, Pozzilli, Italy.
Enrico BaldiniEmergency Department, Policlinico Umberto I Hospital, Sapienza University, Rome, Italy.
Mariangela PeruzziMediterranea Cardiocentro, Napoli, Italy.
Giuliano BertazzoniEmergency Department, Policlinico Umberto I Hospital, Sapienza University, Rome, Italy.
Francesco MenichettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Antonino G M MarulloDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Fabio MiraldiDepartment of Internal Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Andrea MorelliDepartment of Internal Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Giacomo FratiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Roberto CarnevaleMediterranea Cardiocentro, Napoli, Italy.ORCID https://orcid.org/0000-0002-6216-9595
Falcone MarcoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Sapienza University of Rome · ITUniversity of Pisa · ITClinica Mediterranea · ITIstituto Neurologico Mediterraneo · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough preclinical studies highlighted the potential role of NADPH oxidase (NOX) in sepsis, only few studies evaluated the oxidative stress in patients with sepsis and septic shock. The objective of the study is to appraise the oxidative stress status and platelet function in patients with sepsis and septic shock compared to healthy controls. METHODS AND

resultsPatients with sepsis or septic shock admitted to the hospital Policlinico Umberto I (Sapienza University, Rome) underwent a blood sample collection within 1 hour from admission. Platelet aggregation, serum thromboxane B2 (TxB2), soluble NOX2-derived peptides (sNox2-dp), and hydrogen peroxide breakdown activity (HBA) were measured and compared to those of healthy volunteers. Overall, 33 patients were enrolled; of these, 20 (60.6%) had sepsis and 13 (39.4%) septic shock. Compared to healthy controls (

conclusionsPatients with septic shock exhibit higher Nox2 activity and platelet activation than patients with sepsis. These insights joined to better knowledge of these mechanisms could guide the identification of future prognostic biomarkers and new therapeutic strategies in the scenario of septic shock.

Indexed as

Platelet ActivationAgedAged, 80 and overBlood PlateletsDisease-Free SurvivalFemaleHumansMaleMiddle AgedNADPH Oxidase 2Prospective StudiesShock, SepticSurvival RateThromboxane B2CYBB protein, humanNADPH Oxidase 2Thromboxane B2

Identifiers

PMID33194001
PMCPMC7641261
OpenAlexW3096162240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.