Evidence map›Paper›PMID 33194000›Full record

ArticleOxidative medicine and cellular longevity2020

Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats.

Xu Yang, Na Niu, Chen Liang, Ming-Ming Wu, Liang-Liang Tang, Qiu-Shi Wang, Jie Lou, Bin-Lin Song, Wei-Wan Zheng, He-Ping Ma and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. High NaBiomedicines · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xu YangDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Na NiuDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Chen LiangDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Ming-Ming WuDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.ORCID https://orcid.org/0000-0002-6861-6376
Liang-Liang TangDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Qiu-Shi WangDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.ORCID https://orcid.org/0000-0002-4447-9565
Jie LouDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Bin-Lin SongDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.ORCID https://orcid.org/0000-0003-4455-4825
Wei-Wan ZhengDepartment of Pharmacy, The 1st Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
He-Ping MaDepartment of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Zhi-Ren ZhangDepartments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.ORCID https://orcid.org/0000-0003-1324-6934
Harbin Medical University · CNEmory University · US

Funding

Role of Ion Channels in Kidney DiseasesR01DK100582 · NIDDK · EMORY UNIVERSITY · PI MA, HE-PING · 2014 to 2017
$1.4M
NIDDK NIH HHS R01 DK100582
6 · The paper itself

Abstract

Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and

Indexed as

MAP Kinase Signaling SystemAnimalsBone Morphogenetic Protein 4Endothelial CellsEpithelial Sodium ChannelsHypertensionImmediate-Early ProteinsMaleNedd4 Ubiquitin Protein Ligasesp38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesRatsRats, Inbred DahlRats, Sprague-DawleySerum-Glucocorticoid Regulated KinasesBmp4 protein, ratBone Morphogenetic Protein 4Epithelial Sodium ChannelsImmediate-Early ProteinsNEDD4L protein, ratNedd4 Ubiquitin Protein Ligasesp38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated Kinases

Identifiers

PMID33194000
PMCPMC7641672
OpenAlexW3096481088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.