Evidence map›Paper›PMID 33193863›Full record

ArticleAsian journal of pharmaceutical sciences2020

The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy.

Xiaoli Zhang, Tian Zhang, Xianbin Ma, Yajun Wang, Yi Lu, Die Jia, Xiaohua Huang, Jiucun Chen, Zhigang Xu, Feiqiu Wen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Chemical science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoli ZhangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen 518038, China.
Tian ZhangSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Xianbin MaSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Yajun WangSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Yi LuSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Die JiaSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Xiaohua HuangGuangan Changming Research Institute for Advanced Industrial Technology, Guangan 638500, China.
Jiucun ChenSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Zhigang XuSchool of Materials and Energy, Southwest University, Chongqing 400715, China.
Feiqiu WenDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen 518038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin (DOX) prodrug (DOXDT) for enhanced chemotherapy. High-density DOX component was covalently decorated on the nanocarrier and the drug molecules could be effectively released in the acidic tumor tissue/cells, improving chemotherapy efficacy. Specifically, a dextran-based copolymer was preliminarily prepared by one-step atom transfer radical polymerization (ATRP); then DOX was conjugated on the copolymer component

Indexed as

ChemotherapyControlled releaseDextranProdrugTumor acidic microenvironment

Identifiers

PMID33193863
PMCPMC7610203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.