ArticleTherapeutic advances in neurological disorders2020
Dimethyl fumarate transfer into human milk.
Article in Therapeutic advances in neurological disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Interim Analysis of Pregnancy Outcomes After Exposure to Dimethyl Fumarate in a Prospective International Registry.Neurology(R) neuroimmunology & neuroinflammation · 2022Trial
- UK consensus on pregnancy in multiple sclerosis: An update to 'Association of British Neurologists' guidance.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Review
- Editorial: The impact of exposure to environmental chemicals, pharmaceuticals and particles via human breast milk: a focus on health effects and underlying mechanisms.Frontiers in public health · 2025Article
- Topical review: Lactation and use of DMTs in women with MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Review
- Patient-centered pregnancy planning in multiple sclerosis: evidence for a new era.Arquivos de neuro-psiquiatria · 2024Review
- [Pregnancy and breastfeeding in women with multiple sclerosis].Der Nervenarzt · 2024Review
- Early postpartum treatment strategies and early postpartum relapses in women with active multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Very low monomethyl fumarate exposure via human milk: a case report-a contribution from the ConcePTION project.Frontiers in public health · 2024Article
- Clinical Experience with Dimethyl Fumarate and Natalizumab in Pregnant Women with Multiple Sclerosis: A Four-Patient Case Series.Case reports in neurological medicine · 2024Article
- [Esclerosis multiple. Lactancia. Lactante. Planificacion familiar. Posparto. Tratamiento modificador de la enfermedad.]Revista de neurologia · 2023Review
- The protective role of breastfeeding in multiple sclerosis: Latest evidence and practical considerations.Frontiers in neurology · 2022Review
- Disease-Modifying Drugs and Breastfeeding in Multiple Sclerosis: A Narrative Literature Review.Frontiers in neurology · 2022Review
- A systematic review of relapse rates during pregnancy and postpartum in patients with relapsing multiple sclerosis.Therapeutic advances in neurological disorders · 2021Review
- The German Multiple Sclerosis and Pregnancy Registry: rationale, objective, design, and first results.Therapeutic advances in neurological disorders · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) are excreted into human milk. We present two cases of lactating patients who donated milk samples to study the transfer of MMF into human milk following a week of 2 × 240 mg daily oral dose. Samples were analyzed using liquid chromatography mass spectrometry. The calculated relative infant dose was 0.019% and 0.007%. This is the first study to demonstrate that MMF is transferred into human milk, with only limited exposure to an infant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.