ReviewFrontiers in genetics2020
Long-Term Impact of Social Isolation and Molecular Underpinnings.
Review in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Human social isolation and stress: a systematic review of different contexts and recommendations for future studies.Trends in psychiatry and psychotherapy · 2024Pooled it
- Social Isolation Causes Behavioural Abnormalities and Reduces Synaptic Proteins in the Brains ofBiology · 2026Article
- Social Behavior and Neurogenesis.International journal of molecular sciences · 2026Review
- Turning Everything Upside Down: The Impact of Illness on Romantic Relationships-A SEM-Based Actor-Partner Interdependence Model.Family process · 2026Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats.Psychopharmacology · 2025Article
- Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.bioRxiv : the preprint server for biology · 2024Article
- Social isolation impairs cognition via Aβ-mediated synaptic dysfunction.Translational psychiatry · 2024Article
- Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking.Biology of sex differences · 2024Article
- Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.Neurochemical research · 2024Article
- The keystone gut speciesmBio · 2024Article
- Wonder symphony: epigenetics and the enchantment of the arts.Environmental epigenetics · 2024Review
- Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus.BMC genomics · 2023Article
- Social isolation from childhood to mid-adulthood: is there an association with older brain age?Psychological medicine · 2023Article
- Social isolation shortens lifespan through oxidative stress in ants.Nature communications · 2023Article
- Article
- Article
- Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology.Epidemiology and psychiatric sciences · 2022Article
- Blueprints for measuring natural behavior.iScience · 2022Review
- Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice.Behavioural brain research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged periods of social isolation can have detrimental effects on the physiology and behavior of exposed individuals in humans and animal models. This involves complex molecular mechanisms across tissues in the body which remain partly identified. This review discusses the biology of social isolation and describes the acute and lasting effects of prolonged periods of social isolation with a focus on the molecular events leading to behavioral alterations. We highlight the role of epigenetic mechanisms and non-coding RNA in the control of gene expression as a response to social isolation, and the consequences for behavior. Considering the use of strict quarantine during epidemics, like currently with COVID-19, we provide a cautionary tale on the indiscriminate implementation of such form of social isolation and its potential damaging and lasting effects in mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.