Evidence map›Paper›PMID 33193670›Full record

ArticleFrontiers in genetics2020

Impact of a

Tabea Horn, Michael Ludwig, Olaf Eickmeier, Anne H Neerinex, Anke H Maitland-van der Zee, Christina Smaczny, Thomas O F Wagner, Ralf Schubert, Stefan Zielen, Christof Majoor and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04242420 (Impact of Connexin 37, Connexin 43 on Clinical Disease Phenotype in Delta F508 Homozygous Patients With Cystic Fibrosis), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04242420 naunknown statusnot on this map

Impact of Connexin 37, Connexin 43 on Clinical Disease Phenotype in Delta F508 Homozygous Patients With Cystic Fibrosis (CF) (CF-Modifier)

TypeinterventionalSponsorUniversity Childrens' Hospital (Zentrum für Kinderheilkunde des Universitätsklinikum Bonn)Ran2002 to 2024Enrolled300ConditionsCystic Fibrosis, InflammationArmsGenotyping, Lung function, Microbiology, Blood sample, Induced Sputum
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Tabea HornAbt. Allgemeine Pädiatrie, Zentrum für Kinderheilkunde des Universitätsklinikums Bonn, Bonn, Germany.
Michael LudwigInstitut für Klinische Chemie und Klinische Pharmakologie des Universitätsklinikums Bonn, Bonn, Germany.
Olaf EickmeierDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Anne H NeerinexDepartment of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Anke H Maitland-van der ZeeDepartment of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Christina SmacznyChristiane-Herzog CF-Ambulanz, Universitätsklinikum Frankfurt, Frankfurt, Germany.
Thomas O F WagnerChristiane-Herzog CF-Ambulanz, Universitätsklinikum Frankfurt, Frankfurt, Germany.
Ralf SchubertDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Stefan ZielenDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Christof MajoorDepartment of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Lieuwe D BosDepartment of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Sabina Schmitt-GrohéAbt. Allgemeine Pädiatrie, Zentrum für Kinderheilkunde des Universitätsklinikums Bonn, Bonn, Germany.
Goethe University Frankfurt · DEAmsterdam University Medical Centers · NLUniversity of Amsterdam · NLZentrum für Kinderheilkunde · DEUniversity Hospital Bonn · DEUniversity Hospital Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung disease phenotype varies widely even in the

methodsOne-hundred-and-sixteen homozygous

resultsSequence analysis revealed one clinically relevant single nucleotide polymorphism. In this

conclusionsIn carriers of the A allele (27.6%) the CLINICAL

trial registrationThe study was registered with ClinicalTrials.gov, number NCT04242420, retrospectively on January 24th, 2020.

Indexed as

cystic fibrosisF508del homozygousgap junction protein alpha 4-genotypeinflammatory markerslung disease phenotypelung functionphenotype/genotype relationprecision medicine

Identifiers

PMID33193670
PMCPMC7655539
OpenAlexW3096495537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.