Evidence map›Paper›PMID 33193614›Full record

ArticleFrontiers in genetics2020

The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study.

Su Yon Jung, Nicholas Mancuso, Sihao Han, Zuo-Feng Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Su Yon JungTranslational Sciences Section, Jonsson Comprehensive Cancer Center, School of Nursing, University of California, Los Angeles, Los Angeles, CA, United States.
Nicholas MancusoDivision of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Sihao HanDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
Zuo-Feng ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Insulin-Resistance Genetic and Epigenetic Variants and Their Interactions with Lifestyle Factors in Postmenopausal Breast CancerK01NR017852 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JUNG, SU YON · 2019 to 2021
$289k
NINR NIH HHS K01 NR017852
6 · The paper itself

Abstract

backgroundCirculating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive.

methodsOur Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women.

resultsOf 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed.

conclusionOur findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer.

Indexed as

breast cancerdiabetesgenetically determined glucose and insulinMendelian randomizationobesity

Identifiers

PMID33193614
PMCPMC7525156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.