Evidence map›Paper›PMID 33193594›Full record

ArticleFrontiers in genetics2020

Candidate Gene Analysis Reveals Strong Association of

Godfred Agongo, Lucas Amenga-Etego, Engelbert A Nonterah, Cornelius Debpuur, Ananyo Choudhury, Amy R Bentley, Abraham R Oduro, Charles N Rotimi, Nigel J Crowther, Michèle Ramsay and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. International journal of general medicine · 2024
    Article
  2. A Novel HeterozygousJournal of clinical research in pediatric endocrinology · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Godfred AgongoNavrongo Health Research Centre, Navrongo, Ghana.
Lucas Amenga-EtegoNavrongo Health Research Centre, Navrongo, Ghana.
Engelbert A NonterahNavrongo Health Research Centre, Navrongo, Ghana.
Cornelius DebpuurNavrongo Health Research Centre, Navrongo, Ghana.
Ananyo ChoudhurySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.
Abraham R OduroNavrongo Health Research Centre, Navrongo, Ghana.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.
Nigel J CrowtherDepartment of Chemical Pathology, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Michèle RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
AWI-Gen and H3Africa
H AfricaNavrongo Health Research Centre, Navrongo, Ghana.
University of the Witwatersrand · ZANavrongo Health Research Centre · GHNational Health Laboratory Service · ZANational Human Genome Research Institute · USNational Institutes of Health · USUniversity of Ghana · GHUtrecht University · NL

Funding

Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2M
Wits Non-communicable Disease Research Leadership ProgramD43TW008330 · FIC · WITS HEALTH CONSORTIUM (PTY), LTD · PI CROWTHER, NIGEL JOHN, KLIPSTEIN-GROBUSCH, KERSTIN · 2010 to 2014
$985k
FIC NIH HHS D43 TW008330Intramural NIH HHS ZIA HG200362NHGRI NIH HHS U54 HG006938
6 · The paper itself

Abstract

Variations in lipid levels are attributed partly to genetic factors. Genome-wide association studies (GWASs) mainly performed in European, African American and Asian cohorts have identified variants associated with LDL-C, HDL-C, total cholesterol (TC) and triglycerides (TG), but few studies have been performed in sub-Saharan Africans. This study evaluated the effect of single nucleotide variants (SNVs) in eight candidate loci (

Indexed as

AWI-Gencandidate geneGhanaianslipidsingle nucleotide variant

Identifiers

PMID33193594
PMCPMC7661969
OpenAlexW3094737611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.