ReviewFrontiers in immunology2020
Host Immunity and Inflammation to Pulmonary Helminth Infections.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A historical and systematic overview ofParasitology · 2021Pooled it
- Article
- Pathogenic type-2 immunity beyond allergy: the role of Th2 cell heterogeneity in helminth infections.Infection and immunity · 2026Review
- Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism.Mucosal immunology · 2026Article
- IL-11 acts as an alarmin-like pro-inflammatory mediator regulating mucosal responses during helminth infection.Mucosal immunology · 2026Article
- Prevalence of equine lungworm (Frontiers in veterinary science · 2026Article
- Helminth infection modulates the immunogenicity of COVID-19 vaccines in mice without compromising protective efficacy.Frontiers in immunology · 2026Article
- Case Report: Definitive diagnosis of pulmonary parasitic infection via cytomorphology and histopathology in a patient with non-specific pulmonary nodules and hemoptysis after raw deer blood consumption.Frontiers in medicine · 2026Article
- Prevalence and species distribution of intestinal parasites: a four-year retrospective study at Burao general hospital, Somaliland.BMC research notes · 2025Article
- In vitro cytokine response of circulating mononuclear cells from healthy dogs to stage-specific antigens of Angiostrongylus vasorum.BMC veterinary research · 2025Article
- Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical Region.International journal of molecular sciences · 2025Article
- Genetics of helminth infections: Immune system response, insights into host-parasite interaction, and drug resistance.Journal of advanced veterinary and animal research · 2025Article
- Characteristics ofFrontiers in immunology · 2025Article
- A Review on Risk Factors, Traditional Diagnostic Techniques, and Biomarkers for Pneumonia Prognostication and Management in Diabetic Patients.Diseases (Basel, Switzerland) · 2024Review
- Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis.PLoS neglected tropical diseases · 2024Article
- Examining the contribution of Notch signaling to lung disease development.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Ascaris Mouse Model Protocols: Advancing Research on Larval Ascariasis Biology.Current protocols · 2024Article
- Identification and coregulation pattern analysis of long noncoding RNAs in the mouse brain after Angiostrongylus cantonensis infection.Parasites & vectors · 2024Article
- Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies.International journal of molecular sciences · 2024Review
- Dynamics of co-infection in fish: A review of pathogen-host interaction and clinical outcome.Fish and shellfish immunology reports · 2023Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Helminths, including nematodes, cestodes and trematodes, are complex parasitic organisms that infect at least one billion people globally living in extreme poverty. Helminthic infections are associated with severe morbidity particularly in young children who often harbor the highest burden of disease. While each helminth species completes a distinct life cycle within the host, several helminths incite significant lung disease. This impact on the lungs occurs either directly from larval migration and host immune activation or indirectly from a systemic inflammatory immune response. The impact of helminths on the pulmonary immune response involves a sophisticated orchestration and activation of the host innate and adaptive immune cells. The consequences of activating pulmonary host immune responses are variable with several helminthic infections leading to severe, pulmonary compromise while others providing immune tolerance and protection against the development of pulmonary diseases. Further delineation of the convoluted interface between helminth infection and the pulmonary host immune responses is critical to the development of novel therapeutics that are critically needed to prevent the significant global morbidity caused by these parasites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.