Evidence map›Paper›PMID 33193444›Full record

ArticleFrontiers in immunology2020

Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages.

Charles Yin, Angela M Vrieze, Mara Rosoga, James Akingbasote, Emily N Pawlak, Rajesh Abraham Jacob, Jonathan Hu, Neha Sharma, Jimmy D Dikeakos, Lillian Barra and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Autophagy activation by the Becn1Brain, behavior, and immunity · 2026
    Article
  4. GATA2 Mediates Macrophage Proliferation During Atherosclerosis.Journal of the American Heart Association · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. The effect of HLA-DRB1*04:01 on a mouse model of atherosclerosis.Journal of translational autoimmunity · 2023
    Article
  17. Article
  18. Role of the pioneer transcription factor GATA2 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Charles YinDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Angela M VriezeDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Mara RosogaDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
James AkingbasoteDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Emily N PawlakDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Rajesh Abraham JacobDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Jonathan HuDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Neha SharmaDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Jimmy D DikeakosDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Lillian BarraDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
A Dave NagpalDivision of Cardiac Surgery, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Bryan HeitDepartment of Microbiology and Immunology, and The Center for Human Immunology, The University of Western Ontario, London, ON, Canada.
Western University · CA

Funding

CIHR MOP-389413
6 · The paper itself

Abstract

The loss of efferocytosis-the phagocytic clearance of apoptotic cells-is an initiating event in atherosclerotic plaque formation. While the loss of macrophage efferocytosis is a prerequisite for advanced plaque formation, the transcriptional and cellular events in the pre-lesion site that drive these defects are poorly defined. Transcriptomic analysis of macrophages recovered from early-stage human atherosclerotic lesions identified a 50-fold increase in the expression of GATA2, a transcription factor whose expression is normally restricted to the hematopoietic compartment. GATA2 overexpression

Indexed as

Gene ExpressionAnimalsAtherosclerosisCell LineCells, CulturedDisease SusceptibilityExtracellular VesiclesGATA2 Transcription FactorHumansMacrophagesMicePhagocytosisPhagosomesGATA2 protein, humanGATA2 Transcription FactoratherosclerosisefferocytosisGATA2inflammationmacrophagephagocytosisvesicular trafficking

Identifiers

PMID33193444
PMCPMC7644460
OpenAlexW3093579997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.