Evidence map›Paper›PMID 33193411›Full record

ArticleFrontiers in immunology2020

Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by

Jason T Weinfurter, Michael E Graham, Adam J Ericsen, Lea M Matschke, Sian Llewellyn-Lacey, David A Price, Roger W Wiseman, Matthew R Reynolds

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jason T WeinfurterDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Michael E GrahamWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Adam J EricsenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Lea M MatschkeDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Sian Llewellyn-LaceyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Roger W WisemanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Matthew R ReynoldsDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
University of Wisconsin–Madison · USCardiff University · GB

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
CCR5-mutant monkey model to facilitate the development of novel stem cell-based therapies for AIDSR24OD021322 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GOLOS, THADDEUS G, SLUKVIN, IGOR I. · 2016 to 2019
$3.3M
Alloimmunization as a novel prophylactic vaccine for AIDS virusesR01AI118495 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI REYNOLDS, MATTHEW R. · 2015 to 2017
$2.0M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NIAID NIH HHS R01 AI118495NIH HHS P51 OD011106NIH HHS R24 OD021322Wellcome TrustWellcome Trust 100326/Z/12/Z
6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs). The potential to mark malignant and latently infected cells for destruction makes mHAgs attractive targets for cellular immunotherapies. However, testing such HIV reservoir reduction strategies will likely require preclinical studies in non-human primates (NHPs). In this study, we used a combination of alloimmunization, whole exome sequencing, and bioinformatics to identify an mHAg in Mauritian cynomolgus macaques (MCMs). We mapped the minimal optimal epitope to a 10-mer peptide (SW10) in apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3C (APOBEC3C) and determined the major histocompatibility complex class I restriction element as Mafa-A1

Indexed as

AnimalsCD8-Positive T-LymphocytesCytidine DeaminaseDisease Models, AnimalEpitopes, T-LymphocyteMacaca fascicularisMinor Histocompatibility AntigensCytidine DeaminaseEpitopes, T-LymphocyteMinor Histocompatibility AntigensAPOBECCD8 T cellcellular immunotherapycynomolgus macaqueepitopeHIVminor histocompatibility antigen (mHAg)non-human primate (NHP)

Identifiers

PMID33193411
PMCPMC7649366
OpenAlexW3095849890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.