Evidence map›Paper›PMID 33193400›Full record

ArticleFrontiers in immunology2020

Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages.

Lixia Li, Jian Song, Omar Chuquisana, Melanie-Jane Hannocks, Sophie Loismann, Thomas Vogl, Johannes Roth, Rupert Hallmann, Lydia Sorokin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  7. Guided monocyte fate to FRβ/CD163Cellular and molecular life sciences : CMLS · 2024
    Article
  8. Vascular Extracellular Matrix in Atherosclerosis.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lixia LiInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Jian SongInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Omar ChuquisanaInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Melanie-Jane HannocksInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Sophie LoismannInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Thomas VoglCells-in-Motion Interfaculty Centre, University of Muenster, Muenster, Germany.
Johannes RothCells-in-Motion Interfaculty Centre, University of Muenster, Muenster, Germany.
Rupert HallmannInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Lydia SorokinInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins (laminins 411 and 511) in this monocyte to macrophage switch. Chimeric mice carrying CX3CR1-GFP bone marrow were employed to track CCL2-induced monocyte extravasation in a cremaster muscle model using intravital microscopy, revealing faster extravasation in mice lacking endothelial laminin 511 (

Indexed as

AnimalsBasement MembraneCell AdhesionCell DifferentiationCell MovementCells, CulturedCuesEndothelial CellsEndotheliumFemaleHumansHuman Umbilical Vein Endothelial CellsIntegrinsLamininMacrophagesMaleIntegrinsLamininendothelial basement membraneintravital microscopylamininmacrophagemonocyte

Identifiers

PMID33193400
PMCPMC7662115
OpenAlexW3096633873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.