Evidence map›Paper›PMID 33193396›Full record

ArticleFrontiers in immunology2020

Development of Complement Factor H-Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant

Jutamas Shaughnessy, Y Tran, Bo Zheng, Rosane B DeOliveira, Sunita Gulati, Wen-Chao Song, James M Maclean, Keith L Wycoff, Sanjay Ram

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  8. Interactions Between PathogenicFrontiers in cellular and infection microbiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jutamas ShaughnessyDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States.
Y TranPlanet Biotechnology, Inc., Hayward, CA, United States.
Bo ZhengDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States.
Rosane B DeOliveiraDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States.
Sunita GulatiDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States.
Wen-Chao SongDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
James M MacleanPlanet Biotechnology, Inc., Hayward, CA, United States.
Keith L WycoffPlanet Biotechnology, Inc., Hayward, CA, United States.
Sanjay RamDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · USPlanet Biotechnology (United States) · USUniversity of Pennsylvania · US

Funding

Novel immunotherapeutics against multidrug-resistant Neisseria gonorrhoeaR01AI132296 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, RICE, PETER A. · 2017 to 2021
$5.5M
An immunotherapeutic to prevent gonorrheaR44AI147930 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI RAM, SANJAY, WYCOFF, KEITH · 2019 to 2021
$2.0M
NIAID NIH HHS R01 AI132296NIAID NIH HHS R44 AI147930
6 · The paper itself

Abstract

Novel therapeutics against the global threat of multidrug-resistant

Indexed as

Plants, Genetically ModifiedAnimalsAnti-Bacterial AgentsComplement Factor HDrug Resistance, MultipleGonorrheaHumansImmunoglobulin Fc FragmentsImmunoglobulin GImmunotherapyMiceNeisseria gonorrhoeaeNicotianaRecombinant Fusion ProteinsAnti-Bacterial AgentsCFH protein, humanComplement Factor HImmunoglobulin Fc FragmentsImmunoglobulin GRecombinant Fusion Proteinscomplementfactor Hfactor H (FH)Fc fusion proteingonorrheaimmunotherapeuticNeisseria gonorrhoeaeNicotiana benthamiana

Identifiers

PMID33193396
PMCPMC7649208
OpenAlexW3095682718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.