Evidence map›Paper›PMID 33193394›Full record

ArticleFrontiers in immunology2020

Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ.

Andy C Tran, Gil R Diogo, Matthew J Paul, Alastair Copland, Peter Hart, Nickita Mehta, Edward B Irvine, Tufária Mussá, Pascal M W Drake, Juraj Ivanyi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. CD8+ lymphocytes in immunity against tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Secreted proteins ofFrontiers in tuberculosis · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Antigen specificity shapes antibody functions in tuberculosis.bioRxiv : the preprint server for biology · 2024
    Article
  11. Stability Engineering of Recombinant Secretory IgA.International journal of molecular sciences · 2024
    Article
  12. Article
  13. Recombinant neutralizing secretory IgA antibodies for preventing mucosal acquisition and transmission of SARS-CoV-2.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  14. Article
  15. Antibodies as clinical tools for tuberculosis.Frontiers in immunology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Andy C TranInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Gil R DiogoInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Matthew J PaulInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Alastair CoplandInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Peter HartInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Nickita MehtaRagon Institute, Harvard, Cambridge, MA, United States.
Edward B IrvineRagon Institute, Harvard, Cambridge, MA, United States.
Tufária MussáDepartment of Microbiology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Pascal M W DrakeInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
Juraj IvanyiDepartamento de Plataformas Tecnológicas em Saúde, Instituto Nacional de Saúde, Maputo, Mozambique.
Galit AlterRagon Institute, Harvard, Cambridge, MA, United States.
Rajko ReljicInstitute for Infection and Immunity, St. George's University, London, United Kingdom.
St George's, University of London · GBRagon Institute of MGH, MIT and Harvard · USInstituto Nacional de Saúde · MZ

Funding

Exploiting Fc-engineering to dissect mechanisms of anti-microbial action of M. tuberculosis-specific antibodiesF31AI150171 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI IRVINE, EDWARD BUFORD · 2020 to 2021
$64k
NIAID NIH HHS F31 AI150171
6 · The paper itself

Abstract

New evidence has been emerging that antibodies can be protective in various experimental models of tuberculosis. Here, we report on protection against multidrug-resistant

Indexed as

alpha-CrystallinsAnimalsAntibodies, MonoclonalAntigens, BacterialAntigens, CDBacterial LoadBacterial ProteinsDrug Resistance, MultipleHumansImmunoglobulin AInterferon-gammaLungMiceMice, TransgenicMycobacterium tuberculosisNeutrophilsalpha-CrystallinsAntibodies, MonoclonalAntigens, BacterialAntigens, CDBacterial ProteinsFc(alpha) receptorIFNG protein, mouseImmunoglobulin AInterferon-gammaMPB64 protein, MycobacteriumReceptors, FcReceptors, IgGalpha crystallinCD89 (Fc alpha/muR)drug resistanceHspXIgAinterferon-gammamAb—monoclonal antibodytuberculosis

Identifiers

PMID33193394
PMCPMC7606302
OpenAlexW3093875443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.