Evidence map›Paper›PMID 33193374›Full record

ReviewFrontiers in immunology2020

Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells.

Weiwei Chen, Qiang Shu, Jie Fan

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?International journal of molecular sciences · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Neuronal-Immune Cell Units in Allergic Inflammation in the Nose.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weiwei ChenDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Qiang ShuThe Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Jie FanDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Funding

IMPROVEMENT OF ORGAN FUNCTION AFTER SEVERE HYPOVOLEMIAR01HL076179 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PING WANG · 2004 to 2026
$7.6M
Cell Priming, Receptor Cross-Talk, and Acute Lung InjuryR01HL079669 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE, WILSON, MARK A. · 2005 to 2019
$4.0M
Macrophage Pyroptosis Mechanism of Post-Trauma Acute Lung InjuryR01HL139547 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE · 2018 to 2021
$1.6M
Cell Death Mechanism of Acute Lung Injury in SepsisI01BX002729 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2015 to 2020
–
Regulatory Role of ILC2 in Acute Lung Injury in SepsisI01BX004838 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2021 to 2024
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BLR&D Research Career Scientist Award ApplicationIK6BX004211 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2018 to 2022
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BLRD VA I01 BX002729BLRD VA I01 BX004838BLRD VA IK6 BX004211NHLBI NIH HHS R01 HL076179NHLBI NIH HHS R01 HL079669NHLBI NIH HHS R01 HL139547
6 · The paper itself

Abstract

Emerging evidence supports the involvement of nervous system in the regulation of immune responses. Group 2 innate lymphoid cells (ILC2), which function as a crucial bridge between innate and adaptive immunity, are present in large numbers in barrier tissues. Neuropeptides and neurotransmitters have been found to participate in the regulation of ILC2, adding a new dimension to neuroimmunity. However, a comprehensive and detailed overview of the mechanisms of neural regulation of ILC2, associated with previous findings and prospects for future research, is still lacking. In this review, we compile existing information that supports neurons as yet poorly understood regulators of ILC2 in the field of lung innate and adaptive immunity, focusing on neural regulation of the interaction between ILC2 and pulmonary immune cells.

Indexed as

Adaptive ImmunityAnimalsCytokinesHumansImmunity, InnateLungLymphocytesNeuropeptidesNeurotransmitter AgentsCytokinesNeuropeptidesNeurotransmitter Agentsadaptive immunitygroup 2 innate lymphoid cells (ILC2)innate immunitylungneuroimmunity

Identifiers

PMID33193374
PMCPMC7658006

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.