Evidence map›Paper›PMID 33193325›Full record

ArticleFrontiers in immunology2020

Characterization of Polysaccharide A Response Reveals Interferon Responsive Gene Signature and Immunomodulatory Marker Expression.

Carlos A Alvarez, Mark B Jones, John Hambor, Brian A Cobb

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. NontoxigenicMicroorganisms · 2026
    Review
  4. Comparative genomic analysis ofMicrobiology spectrum · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases.International journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carlos A AlvarezDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Mark B JonesDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
John HamborResearch Beyond Borders, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, United States.
Brian A CobbDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USBoehringer Ingelheim (United States) · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
Regulatory Mechanisms of Glycoprotein SialylationR01GM115234 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Brian A Cobb · 2016 to 2026
$5.1M
TRAINING IN GEOGRAPHIC MEDICINE &INFECTIOUS DISEASET32AI007024 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 1985 to 2020
$4.5M
Immunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4M
Antigenic Carbohydrate Structure, Function, and SpecificityR01GM082916 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2009 to 2016
$1.9M
Connecting the microbiota to peripheral immune quiescence by T cell crosstalkF32AI114109 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI JONES, MARK B · 2015 to 2017
$124k
NCI NIH HHS P30 CA043703NIAID NIH HHS F32 AI114109NIAID NIH HHS T32 AI007024NIAID NIH HHS T32 AI089474NIGMS NIH HHS R01 GM082916NIGMS NIH HHS R01 GM115234
6 · The paper itself

Abstract

Polysaccharide A (PSA), a capsular carbohydrate from the commensal gut bacteria

Indexed as

BiomarkersTranscriptomeAnimalsGene Expression ProfilingImmunomodulationInterferonsLymphocyte ActivationLymphoid TissueMicePolysaccharides, BacterialSignal TransductionT-Lymphocyte SubsetsBiomarkersInterferonsPolysaccharides, Bacterialco-regulatory receptorsinterferonmicrobiotapolysaccharidesT cells

Identifiers

PMID33193325
PMCPMC7649347
OpenAlexW3095303863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.