Evidence map›Paper›PMID 33193316›Full record

ArticleFrontiers in immunology2020

Analysis of Spatial Organization of Suppressive Myeloid Cells and Effector T Cells in Colorectal Cancer-A Potential Tool for Discovering Prognostic Biomarkers in Clinical Research.

Natalie Zwing, Henrik Failmezger, Chia-Huey Ooi, Derrek P Hibar, Marta Cañamero, Bruno Gomes, Fabien Gaire, Konstanty Korski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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  10. High density and proximity of CD8Thoracic cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Natalie ZwingEarly Biomarker Development Oncology, pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
Henrik Failmezgerpharma Research and Early Development Informatics (pREDi), Roche Innovation Center Munich, Penzberg, Germany.
Chia-Huey OoiPharmaceutical Sciences-Biomarkers, Bioinformatics and Omics (PS-BiOmics), pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Derrek P HibarProduct Development, Personalized Healthcare Analytics, Genentech, Inc., South San Francisco, CA, United States.
Marta CañameroEarly Biomarker Development Oncology, pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
Bruno GomesEarly Biomarker Development Oncology, pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Fabien GaireEarly Biomarker Development Oncology, pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
Konstanty KorskiEarly Biomarker Development Oncology, pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
Roche Pharma AG (Germany) · DERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and progression of solid tumors such as colorectal cancer (CRC) are known to be affected by the immune system and cell types such as T cells, natural killer (NK) cells, and natural killer T (NKT) cells are emerging as interesting targets for immunotherapy and clinical biomarker research. In addition, CD3

Indexed as

AdultAgedAged, 80 and overBiomarkersColorectal NeoplasmsComputational BiologyDisease SusceptibilityFemaleGene Expression ProfilingHumansImmunohistochemistryImmunomodulationIntestinal MucosaLymphocytes, Tumor-InfiltratingMaleMiddle AgedBiomarkerscolorectal cancercomputational pathologyspatial statisticssuppressive myeloid cellsT cellstumor immune microenvironment

Identifiers

PMID33193316
PMCPMC7658632
OpenAlexW3097644943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.