Evidence map›Paper›PMID 33193315›Full record

ArticleFrontiers in immunology2020

Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response.

Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J Secombes, Azusa Kimoto, Mitsuru Furihata and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

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  7. Transcriptomics of early responses to purifiedFrontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Takuya YamaguchiInstitute of Infectology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Chia Jung ChangInstitute of Infectology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Axel KargerInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Markus KellerInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Florian PfaffInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Eakapol WangkahartScottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Tiehui WangScottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Christopher J SecombesScottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Azusa KimotoInstitute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Mitsuru FurihataNagano Prefectural Fisheries Experimental Station, Nagano, Japan.
Keiichiro HashimotoInstitute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Uwe FischerInstitute of Infectology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Johannes M DijkstraInstitute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Friedrich-Loeffler-Institut · DEFujita Health University · JPUniversity of Aberdeen · GBGunma Prefectural Fisheries Experimental Station · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Related interleukin-2, -15, and -15-like (IL-2, -15, and -15L) are ancient cytokines, with all three genes surviving in extant fish and some mammals. The present study is the first to identify IL-15L functions, namely in rainbow trout. In isolated trout splenocytes, and

Indexed as

ImmunityImmunomodulationAmino Acid SequenceAnimalsCattleGene ExpressionGlycosylationHEK293 CellsHumansImmunophenotypingInterleukin-15Interleukin-15 Receptor alpha SubunitInterleukin-2Lymphocyte SubsetsModels, MolecularPhylogenyInterleukin-15Interleukin-15 Receptor alpha SubunitInterleukin-2STAT5 Transcription FactorevolutionfishIL-15IL-15-likeIL-15RαIL-2type 2 immunity

Identifiers

PMID33193315
PMCPMC7658486
OpenAlexW3097203187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.