Evidence map›Paper›PMID 33193265›Full record

ReviewFrontiers in microbiology2020

The Clustered Regularly Interspaced Short Palindromic Repeat System and Argonaute: An Emerging Bacterial Immunity System for Defense Against Natural Transformation?

Mafeng Liu, Mi Huang, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Ling Zhang, Leichang Pan, Anchun Cheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mafeng LiuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Mi HuangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Mingshu WangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Dekang ZhuResearch Centre of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, China.
Renyong JiaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Shun ChenInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Ling ZhangResearch Centre of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, China.
Leichang PanResearch Centre of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, China.
Anchun ChengInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clustered regularly interspaced short palindromic repeat (CRISPR) systems and prokaryotic Argonaute proteins (Agos) have been shown to defend bacterial and archaeal cells against invading nucleic acids. Indeed, they are important elements for inhibiting horizontal gene transfer between bacterial and archaeal cells. The CRISPR system employs an RNA-guide complex to target invading DNA or RNA, while Agos target DNA using single stranded DNA or RNA as guides. Thus, the CRISPR and Agos systems defend against exogenous nucleic acids by different mechanisms. It is not fully understood how antagonization of these systems occurs during natural transformation, wherein exogenous DNA enters a host cell as single stranded DNA and is then integrated into the host genome. In this review, we discuss the functions and mechanisms of the CRISPR system and Agos in cellular defense against natural transformation.

Indexed as

Argonaute proteinsbacterial immunity systemClustered regularly interspaced short palindromic repeat-Casnatural transformationssDNA

Identifiers

PMID33193265
PMCPMC7642515
OpenAlexW3093697878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.