ArticleFrontiers in psychology2020
Neuronal Avalanches to Study the Coordination of Large-Scale Brain Activity: Application to Rett Syndrome.
Article in Frontiers in psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 19 citations in OpenAlex.
- The role of high-amplitude bursts of high-gamma activity in naturalistic speech and music listening.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Magnetoencephalography Dimensionality Reduction Informed by Dynamic Brain States.The European journal of neuroscience · 2025Article
- Dynamic reconfiguration of aperiodic brain activity supports cognitive functioning in epilepsy: A neural fingerprint identification.iScience · 2025Article
- Neuronal avalanches in temporal lobe epilepsy as a noninvasive diagnostic tool investigating large scale brain dynamics.Scientific reports · 2024Article
- Altered spread of waves of activities at large scale is influenced by cortical thickness organization in temporal lobe epilepsy: a magnetic resonance imaging-high-density electroencephalography study.Brain communications · 2024Article
- Whole-Brain Propagation Delays in Multiple Sclerosis, a Combined Tractography-Magnetoencephalography Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Flexibility of Fast Brain Dynamics and Disease Severity in Amyotrophic Lateral Sclerosis.Neurology · 2022Article
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Authors and funding
11 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Many complex systems, such as the brain, display large-scale coordinated interactions that create ordered patterns. Classically, such patterns have been studied using the framework of criticality, i.e., at a transition point between two qualitatively distinct patterns. This kind of system is generally characterized by a scale-invariant organization, in space and time, optimally described by a power-law distribution whose slope is quantified by an exponent α. The dynamics of these systems is characterized by alternating periods of activations, called avalanches, with quiescent periods. To maximize its efficiency, the system must find a trade-off between its stability and ease of propagation of activation, which is achieved by a branching process. It is quantified by a branching parameter σ defined as the average ratio between the number of activations in consecutive time bins. The brain is itself a complex system and its activity can be described as a series of neuronal avalanches. It is known that critical aspects of brain dynamics are modeled with a branching parameter σ = , and the neuronal avalanches distribution fits well with a power law distribution exponent α = -3/2. The aim of our work was to study a self-organized criticality system in which there was a change in neuronal circuits due to genetic causes. To this end, we have compared the characteristics of neuronal avalanches in a group of 10 patients affected by Rett syndrome, during an open-eye resting-state condition estimated using magnetoencephalography, with respect to 10 healthy subjects. The analysis was performed both in broadband and in the five canonical frequency bands. We found, for both groups, a branching parameter close to 1. In this critical condition, Rett patients show a lower distribution parameter α in the delta and broadband. These results suggest that the large-scale coordination of activity occurs to a lesser extent in RTT patients.
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