Evidence map›Paper›PMID 33192650›Full record

ReviewFrontiers in psychiatry2020

Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.

Joseph J Shaffer, Merry Mani, Samantha L Schmitz, Jia Xu, Nana Owusu, Dee Wu, Vincent A Magnotta, John A Wemmie

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. TNMR in biomedicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joseph J ShafferDepartment of Radiology, University of Iowa, Iowa City, IA, United States.
Merry ManiDepartment of Radiology, University of Iowa, Iowa City, IA, United States.
Samantha L SchmitzDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Jia XuDepartment of Radiology, University of Iowa, Iowa City, IA, United States.
Nana OwusuDepartment of Radiology, University of Iowa, Iowa City, IA, United States.
Dee WuDepartment of Radiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Vincent A MagnottaDepartment of Radiology, University of Iowa, Iowa City, IA, United States.
John A WemmieDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
University of Iowa · USUniversity of Oklahoma Health Sciences Center · US

Funding

University of Iowam - Whole Body 7T MRI ScannerS10RR028821 · NCRR · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2010 to 2010
$8.0M
Cerebellar metabolism, neural circuits, and symptoms in bipolar disorderR01MH111578 · NIMH · UNIVERSITY OF IOWA · PI VINCENT A MAGNOTTA, John A Wemmie · 2017 to 2026
$5.7M
Basolateral amygdala circuits in defensive behavior regulationR01MH113325 · NIMH · UNIVERSITY OF IOWA · PI WEMMIE, JOHN A · 2018 to 2022
$1.8M
Characterization and Enhancement of Functional T1rho ImagingR01EB022019 · NIBIB · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A, WEMMIE, JOHN A · 2017 to 2020
$1.4M
BLRD VA I01 BX004440NCRR NIH HHS S10 RR028821NIBIB NIH HHS R01 EB022019NIMH NIH HHS R01 MH111578NIMH NIH HHS R01 MH113325
6 · The paper itself

Abstract

Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation transfer (CEST) and T1 relaxation in the rotating frame (T1ρ), are emerging as promising tools in the study of neurological and psychiatric illnesses to study brain metabolism. This review describes proton exchange for non-experts, highlights the current status of proton-exchange MRI, and presents advantages and drawbacks of these techniques compared to more traditional methods of imaging brain metabolism, including positron emission tomography (PET) and MR spectroscopy (MRS). Finally, this review highlights new frontiers for the use of CEST and T1ρ in brain research.

Indexed as

chemical exchange saturation transfer (CEST) imagingneuroimagingproton exchangepsychiatric disorders and mental healthT1ρ MRI

Identifiers

PMID33192650
PMCPMC7542226
OpenAlexW3089300732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.