Evidence map›Paper›PMID 33192618›Full record

ArticleFrontiers in physiology2020

Identifying Isl1 Genetic Lineage in the Developing Olfactory System and in GnRH-1 Neurons.

Ed Zandro M Taroc, Raghu Ram Katreddi, Paolo E Forni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Dual Role of DLK1 in GnRH Neuron Ontogeny.Stem cell reviews and reports · 2025
    Article
  3. Article
  4. Article
  5. Spatiotemporal regulation by downstream genes ofFrontiers in cell and developmental biology · 2025
    Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ed Zandro M TarocDepartment of Biological Sciences, The RNA Institute, and the Center for Neuroscience Research, University at Albany, State University of New York, Albany, NY, United States.
Raghu Ram KatreddiDepartment of Biological Sciences, The RNA Institute, and the Center for Neuroscience Research, University at Albany, State University of New York, Albany, NY, United States.
Paolo E ForniDepartment of Biological Sciences, The RNA Institute, and the Center for Neuroscience Research, University at Albany, State University of New York, Albany, NY, United States.
Albany State University · USUniversity at Albany, State University of New York · US

Funding

Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism.R01HD097331 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Paolo E Forni · 2019 to 2026
$2.2M
Molecular Mechanisms Controlling Differentiation and Circuit Formation of Vomeronasal Sensory NeuronsR01DC017149 · NIDCD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FORNI, PAOLO E · 2019 to 2023
$1.8M
Role of inductive signals released by nasal mesenchyme and brain in controlling terminal nerve development and GnRH-1 neuronal migrationR15HD096411 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FORNI, PAOLO E · 2018 to 2018
$450k
NICHD NIH HHS R01 HD097331NICHD NIH HHS R15 HD096411NIDCD NIH HHS R01 DC017149
6 · The paper itself

Abstract

During embryonic development, symmetric ectodermal thickenings [olfactory placodes (OP)] give rise to several cell types that comprise the olfactory system, such as those that form the terminal nerve ganglion (TN), gonadotropin releasing hormone-1 neurons (GnRH-1ns), and other migratory neurons in rodents. Even though the genetic heterogeneity among these cell types is documented, unidentified cell populations arising from the OP remain. One candidate to identify placodal derived neurons in the developing nasal area is the transcription factor Isl1, which was recently identified in GnRH-3 neurons of the terminal nerve in fish, as well as expression in neurons of the nasal migratory mass (MM). Here, we analyzed the Isl1 genetic lineage in chemosensory neuronal populations in the nasal area and migratory GnRH-1ns in mice using

Indexed as

genetic lineage tracingGnRH neuronsIsl1 conditional knock-outIslet-1/Isl1neural crestolfactory neuronsolfactory placodevomeronasal sensory neurons

Identifiers

PMID33192618
PMCPMC7609815
OpenAlexW3093808622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.