ArticleFrontiers in aging neuroscience2020
Metabolomic and Lipidomic Profiling of Preoperative CSF in Elderly Hip Fracture Patients With Postoperative Delirium.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The Effect of General Anesthesia vs. Regional Anesthesia on Postoperative Delirium-A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Metabolome Profiling of Yokukansan in Preventing Postoperative Delirium in Elderly Cancer Patients: A Reverse Translational Study.Psychiatry and clinical neurosciences · 2025Trial
- Blood-Brain Barrier Permeability in Cases of Post-operative Delirium Is Associated with Central Nervous System Phosphatidylcholine Imbalances.Molecular neurobiology · 2026Article
- Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential.npj aging · 2026Article
- Magnetic resonance spectroscopy in hospitalised older people shows age and delirium-specific metabolic changes.Age and ageing · 2026Article
- Predictive role of tear metabolomics in delirium during anesthesia emergence and postoperative period in elderly patients after abdominal surgery.Frontiers in molecular biosciences · 2026Article
- Causal links between mitochondrial genes, cerebrospinal fluid metabolites, and delirium: a mendelian randomization study.Arquivos de neuro-psiquiatria · 2025Article
- Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review.Biomolecules · 2025Review
- Developing a nomogram for postoperative delirium in elderly patients with hip fractures.World journal of psychiatry · 2025Article
- Delirium in the ICU: how much do we know? A narrative review.Annals of medicine · 2024Review
- Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium.Biomolecules · 2024Article
- Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting.Metabolites · 2024Article
- New insights into the treatment of polycystic ovary syndrome: HKDC1 promotes the growth of ovarian granulocyte cells by regulating mitochondrial function and glycolysis.Journal of molecular histology · 2024Article
- Preoperative prognostic nutritional index value as a predictive factor for postoperative delirium in older adult patients with hip fractures: a secondary analysis.BMC geriatrics · 2024Observational
- Fish oil omega-3 Fatty Acids Alleviate Postoperative delirium-like Behavior in aged mice by Attenuating Neuroinflammation and Oxidative Stress.Neurochemical research · 2024Article
- Biomarkers of delirium risk in older adults: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Review
- Article
- Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis.Brain sciences · 2022Review
- The potential link between obstructive sleep apnea and postoperative neurocognitive disorders: current knowledge and possible mechanisms.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Review
- Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. MATERIALS AND
methodsThis nested case control study used untargeted metabolomic and lipidomic analysis to profile the preoperative CSF of patients (
resultsDemographic characteristics of the groups were matched. Eighteen metabolites and thirty-three lipids were dysregulated in the preoperative CSF of POD patients. Pathway enrichment analysis revealed perturbations in D-glutamine and D-glutamate metabolism; glycerophospholipid metabolism; alanine, aspartate and glutamate metabolism; sphingolipid metabolism; histidine metabolism; and arginine biosynthesis at the pre-delirium stage. Receiver operating characteristic curve analysis indicated that phosphatidylethanolamine (PE, 40:7e), with an area under the curve value of 0.92, is a potential biomarker for POD.
conclusionMultiple pathological mechanisms in the POD group were involved before surgery, including neuroinflammation, oxidative stress, and energy metabolism disorders induced by hypoxia, as well as neurotransmitter imbalances such as increased dopamine and glutamate, and decreased glutamine. These metabolic abnormalities potentially increase the fragility of the brain, thus contributing to POD. PE (40:7e) might be a potential biomarker for POD. Not only do our results provide potential biomarkers for POD, but also provide information for deep pathological research. CLINICAL
trial registrationwww.ClinicalTrials.gov, identifier ChiCTR1900021533.
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