ArticleFrontiers in aging neuroscience2020
Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Association of inflammation and cognition in the elderly: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.Neurobiology of aging · 2026Article
- Sex-specific immune-brain coupling in hippocampal circuits and Alzheimer's disease vulnerability.Research square · 2026Article
- Diabetes and Hypertension at Midlife Predict Increases in Biomarkers of Dementia Among Black Americans.Journal of racial and ethnic health disparities · 2026Article
- Projected Cognitive and Brain Aging Benefits of Eliminating Cardiometabolic Risks in Non-Hispanic White and Black Males - HABS-HD.Journal of racial and ethnic health disparities · 2026Article
- Relations of left ventricular mass and hypertrophy to cognitive function in urban dwelling African American and White adults.Neuropsychology · 2026Article
- The Association Between Age of Menopause and Hysterectomy Status and Alzheimer's Disease Risk in a Cohort of Older White and Black Women.Journal of women's health (2002) · 2025Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Cerebrospinal fluid biomarkers of inflammation and immune activation associated with neurocognitive impairment among US Latinos with HIV.AIDS (London, England) · 2025Article
- Measuring the Interrelationships Between Cognitive Performance, Race/Ethnicity, Discrimination, Health Behaviors, and Physiological Dysregulation: A Path Analysis of the Multi-Ethnic Study of Atherosclerosis.Journal of aging and health · 2025Article
- Associations of high-sensitivity C-reactive protein with neuropsychological outcomes and cerebral white matter hyperintensities in older adults at risk of dementia.Brain, behavior, & immunity - health · 2025Article
- Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition.Ageing research reviews · 2024Review
- Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans.Neurobiology of aging · 2024Article
- Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank.Neurology · 2024Article
- Personal Mastery Attenuates the Association between Greater Perceived Discrimination and Lower Amygdala and Anterior Hippocampal Volume in a Diverse Sample of Older Adults.bioRxiv : the preprint server for biology · 2024Article
- Heart Rate Variability and Cognition: A Narrative Systematic Review of Longitudinal Studies.Journal of clinical medicine · 2024Review
- Looking Upstream to Understand Race/Ethnicity as a Moderator for Poststroke Neuroinflammation and a Social Determinant for Poststroke Aphasia Outcomes.American journal of speech-language pathology · 2024Article
- Association of white matter hyperintensities and clinical vascular burden with depressive symptoms in Black older adults.International journal of geriatric psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesNon-Latino Black adults have greater risk for Alzheimer's dementia compared to non-Latino White adults, possibly due to factors disproportionally affecting Black adults including cardiovascular disease (CVD). Chronic peripheral inflammation is implicated in both Alzheimer's dementia and CVD and is known to impact cognition and cerebral white matter, yet little work has examined these associations by race. This study examined associations between inflammation, cognition, and cerebral white matter generally, and by race.
methodsEighty-six non-demented older Black and White participants (age = 69.03; 50% female; 45% Black participants) underwent fasting venipuncture, cognitive testing, and MRI. Serum was assayed for interleukin-6 (IL-6), C-reactive protein (CRP), and interleukin 1-beta. Cognitive domains included memory, executive function, and attention/information processing. MRI measures included white matter hyperintensity volumes (WMH) and quantification of white matter integrity in areas outside WMHs via DTI-derived fractional anisotropy (FA) and mean diffusivity, as well as multi-component relaxometry derived myelin water fraction (MWF).
resultsBlack and White participants did not differ on age, sex, or CVD risk. Separate linear regression models adjusting for relevant confounders revealed that higher IL-6 associated with lower executive function and higher CRP levels associated with lower FA and MWF. Stratified analyses revealed that these association were significant for Black participants only. DISCUSSION: These findings suggest that peripheral inflammation is inversely associated with select cognitive domains and white matter integrity (but not WMHs), particularly in older Black adults. It is important to consider race when investigating inflammatory associates of brain and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.