Evidence map›Paper›PMID 33192449›Full record

ArticleFrontiers in aging neuroscience2020

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons.

Emily Machiela, Ritika Jeloka, Nicholas S Caron, Shagun Mehta, Mandi E Schmidt, Helen J E Baddeley, Colton M Tom, Nalini Polturi, Yuanyun Xie, Virginia B Mattis and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington's Disease into Striatal Neurons to Create Models of Pathology.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024
    Article
  3. Article
  4. Review
  5. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons.International journal of molecular sciences · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Fountain of youth-Targeting autophagy in aging.Frontiers in aging neuroscience · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Emily MachielaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
Ritika JelokaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
Nicholas S CaronCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Shagun MehtaThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Mandi E SchmidtCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Helen J E BaddeleyCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Colton M TomThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Nalini PolturiBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
Yuanyun XieBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
Virginia B MattisThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Michael R HaydenCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Amber L SouthwellBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.
University of British Columbia · CAUniversity of Central Florida · USCedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (

Indexed as

DNA damageHuntington (disease)iPSC (induced pluripotent stem cell)mouse models of diseaseneurodegenarationprimary neuron culture

Identifiers

PMID33192449
PMCPMC7531251
OpenAlexW3087584071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.