ArticleFrontiers in human neuroscience2020
Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER).
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Connectome-Based Predictive Models Optimized for Sleep Differentiate Patients With Depression From Psychiatrically Healthy Controls.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Review
- Peripheral MicroRNA Signatures in Adolescent Depression.Biological psychiatry global open science · 2025Article
- Threat- and reward-related brain circuitry, perceived stress, and anxiety in adolescents during the COVID-19 pandemic: a longitudinal investigation.Social cognitive and affective neuroscience · 2024Article
- Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.Biological psychiatry global open science · 2024Article
- Neural correlates of depression-related smartphone language use in adolescents.NPP - digital psychiatry and neuroscience · 2024Article
- Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.Psychological medicine · 2023Article
- Inflammatory cytokines and callosal white matter microstructure in adolescents.Brain, behavior, and immunity · 2022Article
- Sex differences in myelin content of white matter tracts in adolescents with depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.Translational psychiatry · 2021Article
- Smaller caudate gray matter volume is associated with greater implicit suicidal ideation in depressed adolescents.Journal of affective disorders · 2021Article
- Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents.Frontiers in psychiatry · 2021Article
- Perspective on adolescent psychiatric illness and emerging role of microRNAs as biomarkers of risk.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
This article provides an overview of the study protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal study in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls in order to examine the inflammatory and glutamatergic pathways that contribute to the recurrence of depression in adolescents. TIGER is the first study to examine the effects of peripheral inflammation on neurodevelopmental trajectories by assessing changes in cortical glutamate in depressed adolescents. Here, we describe the scientific rationale, design, and methods for the TIGER project. This article is intended to serve as an introduction to this project and to provide details for investigators who may be seeking to replicate or extend these methods for other related research endeavors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.