ArticleFrontiers in human neuroscience2020
Case Report of Dual-Site Neurostimulation and Chronic Recording of Cortico-Striatal Circuitry in a Patient With Treatment Refractory Obsessive Compulsive Disorder.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03184454 (Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Pallidal alpha activity is an electrophysiological biomarker of symptom severity in obsessive-compulsive disorder.Research square · 2026Article
- Explainability in AI-enabled medical neurotechnology: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Deep Brain Stimulation Response Circuits in Obsessive-Compulsive Disorder.Biological psychiatry · 2026Review
- Recalibrating the mind: The connectomic and ethical renaissance of laser-guided precision psychosurgery for refractory affective illness.Surgical neurology international · 2026Article
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- Intracranial electrophysiological biomarkers of compulsivity in obsessive-compulsive disorder.Nature. Mental health · 2025Article
- Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.Nature biomedical engineering · 2025Review
- Neuromuscular electrical stimulation at submaximal intensity combined with motor imagery increases corticospinal excitability.European journal of applied physiology · 2025Article
- Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.Frontiers in psychiatry · 2025Review
- Neural decoding and feature selection methods for closed-loop control of avoidance behavior.Journal of neural engineering · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Dual Treatment of Refractory Focal Epilepsy and Obsessive-Compulsive Disorder With Intracranial Responsive Neurostimulation.Neurology. Clinical practice · 2024Review
- Neural Decoding and Feature Selection Techniques for Closed-Loop Control of Defensive Behavior.bioRxiv : the preprint server for biology · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model.Nature communications · 2023Article
- Wearable and Mobile Technologies for the Evaluation and Treatment of Obsessive-Compulsive Disorder: Scoping Review.JMIR mental health · 2023Article
- Article
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- Targeted neuroplasticity in spatiotemporally patterned invasive neuromodulation therapies for improving clinical outcomes.Frontiers in neuroinformatics · 2023Article
- Physiologically informed neuromodulation.Journal of the neurological sciences · 2022Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
Abstract
Psychiatric disorders are increasingly understood as dysfunctions of hyper- or hypoconnectivity in distributed brain circuits. A prototypical example is obsessive compulsive disorder (OCD), which has been repeatedly linked to hyper-connectivity of cortico-striatal-thalamo-cortical (CSTC) loops. Deep brain stimulation (DBS) and lesions of CSTC structures have shown promise for treating both OCD and related disorders involving over-expression of automatic/habitual behaviors. Physiologically, we propose that this CSTC hyper-connectivity may be reflected in high synchrony of neural firing between loop structures, which could be measured as coherent oscillations in the local field potential (LFP). Here we report the results from the pilot patient in an Early Feasibility study (https://clinicaltrials.gov/ct2/show/NCT03184454) in which we use the Medtronic Activa PC+ S device to simultaneously record and stimulate in the supplementary motor area (SMA) and ventral capsule/ventral striatum (VC/VS). We hypothesized that frequency-mismatched stimulation should disrupt coherence and reduce compulsive symptoms. The patient reported subjective improvement in OCD symptoms and showed evidence of improved cognitive control with the addition of cortical stimulation, but these changes were not reflected in primary rating scales specific to OCD and depression, or during blinded cortical stimulation. This subjective improvement was correlated with increased SMA and VC/VS coherence in the alpha, beta, and gamma bands, signals which persisted after correcting for stimulation artifacts. We discuss the implications of this research, and propose future directions for research in network modulation in OCD and more broadly across psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.