Evidence map›Paper›PMID 33192348›Full record

ArticleFrontiers in systems neuroscience2020

Spinal Cord Imaging Markers and Recovery of Volitional Leg Movement With Spinal Cord Epidural Stimulation in Individuals With Clinically Motor Complete Spinal Cord Injury.

Enrico Rejc, Andrew C Smith, Kenneth A Weber, Beatrice Ugiliweneza, Robert J Bert, Mohammadjavad Negahdar, Maxwell Boakye, Susan J Harkema, Claudia A Angeli

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05669508 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

The Reynolds Innovative Spinal Electrical Stimulation (RISES) Program: Transcutaneous Spinal Cord Stimulation

TypeinterventionalSponsorThomas Jefferson UniversityRan2022 to 2026Enrolled4ConditionsSpinal Cord Injuries, Spinal Cord DiseasesArmsRISES-T System, Occupational/Physical Therapy
NCT05966896 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury: Spared Fibers Proof-of-concept Study

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2027Enrolled2ConditionsSpinal Cord InjuriesArmsimplanted epidural stimulator
NCT05994846 nasuspendednot on this mapstarted 2023, after this paper: background citation

The Reynolds Innovative Spinal Electrical Stimulation Program: Transcutaneous Stimulation (RISES-T 2.0)

TypeinterventionalSponsorThomas Jefferson UniversityRan2023 to 2026Enrolled10ConditionsSpinal Cord Injuries, Spinal Cord DiseasesArmsRISES-T System
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  13. Transcutaneous Spinal Stimulation From Adults to Children: A Review.Topics in spinal cord injury rehabilitation · 2023
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Enrico RejcKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.
Andrew C SmithUniversity of Colorado School of Medicine, Department of Physical Medicine and Rehabilitation, Physical Therapy Program, Aurora, CO, United States.
Kenneth A WeberDepartment of Anethesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.
Beatrice UgiliwenezaKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.
Robert J BertDepartment of Radiology, University of Louisville, Louisville, KY, United States.
Mohammadjavad NegahdarDepartment of Radiology, University of Louisville, Louisville, KY, United States.
Maxwell BoakyeKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.
Susan J HarkemaKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.
Claudia A AngeliKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.
Neurological Surgery · USUniversity of Louisville · USRehabilitation Institute of Michigan · USStanford University · USUniversity of Colorado Denver · US

Funding

Neuroimaging-Based Brain and Spinal Cord Biomarkers for Cervical RadiculopathyK23NS104211 · NINDS · STANFORD UNIVERSITY · PI WEBER, KENNETH ARNOLD · 2018 to 2022
$875k
MRI and machine learning to improve early prognosis and clinical management after spinal cord injuryR03HD094577 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2019 to 2020
$195k
NICHD NIH HHS R03 HD094577NINDS NIH HHS K23 NS104211NINDS NIH HHS L30 NS108301
6 · The paper itself

Abstract

Previous studies have shown that epidural stimulation of the lumbosacral spinal cord (scES) can re-enable lower limb volitional motor control in individuals with chronic, clinically motor complete spinal cord injury (SCI). This observation entails that residual supraspinal connectivity to the lumbosacral spinal circuitry still persisted after SCI, although it was non-detectable when scES was not provided. In the present study, we aimed at exploring further the mechanisms underlying scES-promoted recovery of volitional lower limb motor control by investigating neuroimaging markers at the spinal cord lesion site

Indexed as

epidural stimulationspinal cord injuryspinal cord lesionspinal cord MRIspinal tractsvoluntary movement

Identifiers

PMID33192348
PMCPMC7654217
OpenAlexW3094406514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.