Evidence map›Paper›PMID 33192321›Full record

ReviewFrontiers in cellular neuroscience2020

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles.

Susana R Cerqueira, Nagi G Ayad, Jae K Lee

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Susana R CerqueiraDepartment of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Nagi G AyadDepartment of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Jae K LeeDepartment of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Neurological Surgery · US

Funding

Targeting Lipid Clearance Pathways to Promote Repair After SCIR01NS081040 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Jae K Lee · 2012 to 2026
$5.3M
NINDS NIH HHS R01 NS081040
6 · The paper itself

Abstract

The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is emerging as a common feature to target in most CNS pathologies. Recent studies suggest that targeted delivery of small molecules to reduce neuroinflammation can be beneficial. However, suboptimal drug delivery to the CNS is a major barrier to modulate inflammation because neurotherapeutic compounds are currently being delivered systemically without spatial or temporal control. Emerging nanomaterial technologies are providing promising and superior tools to effectively access neuropathological tissue in a controlled manner. Here we highlight recent advances in nanomaterial technologies for drug delivery to the CNS. We propose that state-of-the-art nanoparticle drug delivery platforms can significantly impact local CNS bioavailability of pharmacological compounds and treat neurological diseases.

Indexed as

cell targetingCNSdrug deliverymultifunctional nanoparticlesnanoparticlesneuroinflammationstimuli-responsivetheranostics

Identifiers

PMID33192321
PMCPMC7555434
OpenAlexW3090706329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.