Evidence map›Paper›PMID 33192250›Full record

ArticleFrontiers in neuroscience2020

Using Minimal-Redundant and Maximal-Relevant Whole-Brain Functional Connectivity to Classify Bipolar Disorder.

Yen-Ling Chen, Pei-Chi Tu, Tzu-Hsuan Huang, Ya-Mei Bai, Tung-Ping Su, Mu-Hong Chen, Yu-Te Wu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  5. Pattern of frustration formation in the functional brain network.Network neuroscience (Cambridge, Mass.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yen-Ling ChenInstitute of Biophotonics, National Yang-Ming University, Taipei, Taiwan.
Pei-Chi TuDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Tzu-Hsuan HuangInstitute of Biophotonics, National Yang-Ming University, Taipei, Taiwan.
Ya-Mei BaiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Tung-Ping SuDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Mu-Hong ChenDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Yu-Te WuInstitute of Biophotonics, National Yang-Ming University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA number of mental illness is often re-diagnosed to be bipolar disorder (BD). Furthermore, the prefronto-limbic-striatal regions seem to be associated with the main dysconnectivity of BD. Functional connectivity is potentially an appropriate objective neurobiological marker that can assist with BD diagnosis.

methodsHealth controls (HC;

resultsThe mean accuracy of the 10 testing sets was 76.25%, and the area under the curve was 0.840. The selected functional within-network/between-network connectivity was mainly in the subcortical/cerebellar regions and the frontoparietal network. Furthermore, similarity within the BD patients, calculated by the cosine distance between two functional connectivity matrices, was smaller than between groups before feature selection and greater than between groups after the feature selection. LIMITATIONS: The major limitations were that all the BD patients were receiving medication and that no independent dataset was included.

conclusionOur approach effectively separates a relatively large group of BD patients from HCs. This was done by selecting functional connectivity, which was more similar within BD patients, and also seems to be related to the neuropathological factors associated with BD.

Indexed as

bipolar disorderclassificationfeature selectionfunctional connectivitymachine learning

Identifiers

PMID33192250
PMCPMC7641629
OpenAlexW3094350577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.