ArticleFrontiers in neuroscience2020
Beneficial Cardiac Structural and Functional Adaptations After Lumbosacral Spinal Cord Epidural Stimulation and Task-Specific Interventions: A Pilot Study.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.Nature medicine · 2022Trial
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Effect of epidural spinal cord stimulation in individuals with sensorimotor complete spinal cord injury: a pilot study.Frontiers in systems neuroscience · 2025Article
- Effects of percutaneously-implanted epidural stimulation on cardiovascular autonomic function and spasticity after complete spinal cord injury: A case report.Frontiers in neuroscience · 2023Article
- Article
- Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury.Scientific reports · 2022Article
- Epidural stimulation with locomotor training ameliorates unstable blood pressure after tetraplegia. A case report.Annals of clinical and translational neurology · 2022Article
- Invasive and Non-Invasive Approaches of Electrical Stimulation to Improve Physical Functioning after Spinal Cord Injury.Journal of clinical medicine · 2021Review
- Effects of a Tailored Physical Activity Intervention on Cardiovascular Structure and Function in Individuals With Spinal Cord Injury.Neurorehabilitation and neural repair · 2021Article
- Impact of long-term epidural electrical stimulation enabled task-specific training on secondary conditions of chronic paraplegia in two humans.The journal of spinal cord medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac myocyte atrophy and the resulting decreases to the left ventricular mass and dimensions are well documented in spinal cord injury. Therapeutic interventions that increase preload can increase the chamber size and improve the diastolic filling ratios; however, there are no data describing cardiac adaptation to chronic afterload increases. Research from our center has demonstrated that spinal cord epidural stimulation (scES) can normalize arterial blood pressure, so we decided to investigate the effects of scES on cardiac function using echocardiography. Four individuals with chronic, motor-complete cervical spinal cord injury were implanted with a stimulator over the lumbosacral enlargement. We assessed the cardiac structure and function at the following time points: (a) prior to implantation; (b) after scES targeted to increase systolic blood pressure; (c) after the addition of scES targeted to facilitate voluntary (i.e., with intent) movement of the trunk and lower extremities; and (d) after the addition of scES targeted to facilitate independent, overground standing. We found significant improvements to the cardiac structure (left ventricular mass = 10 ± 2 g,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.