Evidence map›Paper›PMID 33192244›Full record

ArticleFrontiers in neuroscience2020

The Effect and Optimal Dosage of Dexmedetomidine Plus Sufentanil for Postoperative Analgesia in Elderly Patients With Postoperative Delirium and Early Postoperative Cognitive Dysfunction: A Single-Center, Prospective, Randomized, Double-Blind, Controlled Trial.

Wenshuai Zhao, Yanan Hu, Hui Chen, Xifan Wang, Liping Wang, Yu Wang, Xiaohong Wu, Fei Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  16. A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wenshuai ZhaoDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Yanan HuDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Hui ChenDepartment of Anesthesiology, Heilongjiang Provincial Corps Hospital, Chinese People's Armed Police Forces, Harbin, China.
Xifan WangDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Liping WangDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Yu WangDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Xiaohong WuDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Fei HanDepartment of Anesthesiology, The Third Affiliated Hospital, Harbin Medical University, Harbin, China.
Third Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNChinese People's Armed Police Force

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common complications after major surgery among elderly patients. Dexmedetomidine (DEX) is less frequently explored for its effects in patients with postoperative neurocognitive disorders. This study investigated the effect and optimal dosage of DEX for patient-controlled analgesia (PCA) on POD and early POCD after major surgery among elderly patients.

methodsPatients in four groups received continuous infusion of DEX 0, 100, 200, and 400 μg with sufentanil 150 μg for PCA immediately after surgery. POD and POCD were assessed on postoperative days 1, 2, 3, and 7 by using the Confusion Assessment Method (CAM) and Mini-Mental State Examination (MMSE) scales. Furthermore, the incidence of POD and POCD of all the four groups in postoperative 7 days classified by high risk factors (age, education, surgical site, and surgical category), sedation level, postoperative pain intensity, and side effects were assessed.

resultsThe overall incidence rates of POD and early POCD 7 days after surgery were lower in the DEX 200 μg 400 μg groups than in the DEX 0 μg and 100 μg groups (

conclusionThe continuous infusion of DEX 200 μg or DEX 400 μg in PCA significantly decreased the incidence of POD and early POCD after major surgery without increasing any side effects. Compared with DEX 200 μg, DEX 400 μg was preferred for reducing early POCD in patients who underwent open surgery.

Indexed as

dexmedetomidineelderly patientspatient-controlled analgesiapostoperative cognitive dysfunctionpostoperative delirium

Identifiers

PMID33192244
PMCPMC7645155
OpenAlexW3093934766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.