ArticleInternational journal of health sciences
Biochemical studies on the protective effect of honey against doxorubicin-induced toxicity in BALB/C mice.
Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models.Frontiers in cardiovascular medicine · 2022Pooled it
- Honey and cancer: from traditional medicine to modern adjuvant therapy.Frontiers in oncology · 2026Review
- From Chemical Composition to Antiproliferative Effects Through In Vitro Studies: Honey, an Ancient and Modern Hot Topic Remedy.Nutrients · 2025Review
- The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review.Journal of xenobiotics · 2024Review
- Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery.RSC advances · 2024Review
- Protective potentials of polymyxin B and honey against bacterial lipopolysaccharide-induced endotoxemia in mice.Journal of advanced veterinary and animal research · 2024Article
- Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats.International journal of molecular sciences · 2024Article
- Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Roles of Honey, Royal Jelly, and Propolis in Suppressing Nephrotoxicity Induced by Doxorubicin in Male Albino Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Mycochemistry, antioxidant content, and antioxidant potentiality of the ethanolic extract ofInternational journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDoxorubicin-mediated chemotherapy has been linked in cancer patients with acute toxic manifestations. This study aimed to assess the protective effect of natural honey against doxorubicin-induced toxicity in mice.
methodsForty male BALB/C mice were divided randomly and equally into four groups of ten mice. Group I was on a normal diet and served as the control. Group II received only honey to investigate its antitoxic effects (oral administration at 10 g/kg for 10 days). Group III was injected with a single dose of doxorubicin (10 mg/kg i.p.). Group IV received both doxorubicin and honey. On day 11, blood was taken from the various groups of mice and the quantitative and qualitative changes were observed in the white blood cells. The levels of hepatic, renal, and cardiac toxicity biomarkers including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), blood nitrogen urea (BUN), serum creatinine, lactate dehydrogenase (LDH), and creatinine kinase (CK) were also assessed.
resultsThis study revealed that doxorubicin caused acute toxicity, including weight loss, depletion of white blood cells, and altered liver, kidney, and cardiac parameters (
conclusionThe findings suggest that the consumption of natural honey can alleviate doxorubicin-induced toxicity in cancer patients.
Indexed as
Identifiers
33192229PMC7644457W3103251443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.