Evidence map›Paper›PMID 33192176›Full record

ArticleMediators of inflammation2020

Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3

Yingui Li, Yijing Zhao, Xiaoqin Tan, Jiayan Liu, Yingkun Zhi, Lang Yi, Shasha Bai, Qun Du, Qing X Li, Yan Dong

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. International journal of molecular sciences · 2025
    Article
  6. Article
  7. Bamboo Leaf Flavonoids fromInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Journal of experimental pharmacology · 2025
    Review
  11. Antioxidants (Basel, Switzerland) · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Acai Berry (Life (Basel, Switzerland) · 2023
    Article
  18. Isoorientin ameliorates OVA-induced asthma in a murine model of asthma.Experimental biology and medicine (Maywood, N.J.) · 2022
    Article
  19. Anti-Inflammatory Effects of Phytochemical Components ofMolecules (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yingui LiScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0002-8559-9619
Yijing ZhaoScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0001-8243-8505
Xiaoqin TanScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0001-7929-1178
Jiayan LiuScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0003-3475-0742
Yingkun ZhiScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0001-5847-547X
Lang YiScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0002-9321-9022
Shasha BaiScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0002-7821-3749
Qun DuScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
Qing X LiDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.ORCID https://orcid.org/0000-0003-4589-2869
Yan DongScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0003-0915-6223
Guangzhou University of Chinese Medicine · CNUniversity of Hawaiʻi at Mānoa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3

Indexed as

AnimalsEndotoxemiaEnzyme-Linked Immunosorbent AssayExtracellular Signal-Regulated MAP KinasesGlycogen Synthase Kinase 3 betaHeme Oxygenase-1Heterocyclic Compounds, 3-RingInflammationInterleukin-6Lithium ChlorideLuteolinMacrophagesMaleMembrane ProteinsMiceMice, Inbred BALB CExtracellular Signal-Regulated MAP KinasesGlycogen Synthase Kinase 3 betaGsk3b protein, mouseHeme Oxygenase-1Heterocyclic Compounds, 3-RingHmox1 protein, mousehomoorientinInterleukin-6interleukin-6, mouseLithium ChlorideLuteolinMembrane ProteinsMK 2206Nfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa B p50 SubunitNfkb1 protein, mouseOccludinOcln protein, mouseTjp1 protein, mouseZonula Occludens-1 Protein

Identifiers

PMID33192176
PMCPMC7641714
OpenAlexW3097319598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.