Evidence map›Paper›PMID 33192052›Full record

ArticleDrug design, development and therapy2020

Effects of Snake-Derived Phospholipase A2 Inhibitors on Acute Pancreatitis: In vitro and in vivo Characterization.

Yanping Wu, Gen-You Liao, Hua-Jing Ke, Pi Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yanping WuDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
Gen-You LiaoDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
Hua-Jing KeDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
Pi LiuDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.
First Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to investigate the effects of snake-derived phospholipase A2 inhibitor (PLA2) from

methodsThe levels of platelet-activating factor (PAF) and tumor necrosis factor (TNF)-α were detected by ELISA, and the characteristics of autophagy were detected by transmission electron microscopy and Western blotting (LC3, p62, and ATG5).

resultsIn vitro experiments showed that PLA2 treatment caused obvious formation of autophagic bodies. By contrast,

conclusion

Indexed as

AnimalsCells, CulturedDisease Models, AnimalInjections, IntraperitonealMicePancreatitisPeptidesPhospholipase A2 InhibitorsPhospholipases A2RatsSnakesPeptidesPhospholipase A2 InhibitorsPhospholipases A2acute pancreatitisautophagyPLA2snake-derived PLI

Identifiers

PMID33192052
PMCPMC7656965
OpenAlexW3095920679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.