Evidence map›Paper›PMID 33191958›Full record

ArticleTetrahedron letters2020

A click-ready pH-triggered phosphoramidate-based linker for controlled release of monomethyl auristatin E.

Feyisola P Olatunji, Jacob W Herman, Brittany N Kesic, Damilola Olabode, Clifford E Berkman

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Liposomes in Cancer Therapy: How Did We Start and Where Are We Now.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Modular Smart Molecules for PSMA-Targeted Chemotherapy.Molecular cancer therapeutics · 2022
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Feyisola P OlatunjiWashington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States.
Jacob W HermanWashington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States.
Brittany N KesicWashington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States.
Damilola OlabodeWashington State University, Department of Mathematics and Statistics, PO Box 643113, Pullman, WA 99164-3113, United States.
Clifford E BerkmanWashington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States.

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
PSMA - Targeted Small-Molecule Drug ConjugatesR21CA223121 · NCI · WASHINGTON STATE UNIVERSITY · PI BERKMAN, CLIFFORD · 2018 to 2019
$375k
NCI NIH HHS R21 CA223121NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapidly releasing its payload at acidic pH. The linker can also be tailored to release payloads of diverse functional groups, broadening its applications.

Indexed as

Cleavable linkerMMAEMonomethyl auristatin EPayload click-readyPhosphoramidate

Identifiers

PMID33191958
PMCPMC7665082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.