Evidence map›Paper›PMID 33191912›Full record

ArticleeLife2020

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict.

James B Eaglesham, Kacie L McCarty, Philip J Kranzusch

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
0.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  8. Article
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  15. Review
  16. Evolutionary immunology to explore original antiviral strategies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  17. Review
  18. Primal FEAR protects against infection.Nature microbiology · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James B EagleshamDepartment of Microbiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-5725-0743
Kacie L McCartyDepartment of Microbiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-5174-1904
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-4943-733X
Harvard University · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
MOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
NCRR NIH HHS S10 RR029205NIAID NIH HHS T32 AI007245NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103403
6 · The paper itself

Abstract

DNA viruses in the family

Indexed as

AnimalsBinding SitesCloning, MolecularDeoxyribonucleasesEvolution, MolecularGenomeLepidopteraMammalsModels, MolecularNucleotides, CyclicPeptide HydrolasesProtein ConformationRNA VirusesVaccinia virusViral Proteinscyclic guanosine monophosphate-adenosine monophosphateDeoxyribonucleasesNucleotides, CyclicPeptide HydrolasesViral ProteinscGAMPcGASimmune evasioninfectious diseasemicrobiologymolecular biophysicsnonepoxinSTINGstructural biologyvirology

Identifiers

PMID33191912
PMCPMC7688311
OpenAlexW3103267099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.