Evidence map›Paper›PMID 33191858›Full record

ArticleTechnology in cancer research & treatment

Therapeutic Efficacy of Delta-Like Ligand 4 Gene Vaccine Overexpression on Liver Cancer in Mice.

Yi Yu, Yang Zhao, Guangming Zhou, Xiang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi YuKey Laboratory of Digestive Disease, Gansu Province, 12426Lanzhou University Second Hospital, Lanzhou, China.ORCID 0000-0002-4891-451X
Yang ZhaoKey Laboratory of Digestive System Tumors, Gansu Province, 12426Lanzhou University Second Hospital, Lanzhou, China.
Guangming ZhouDepartment of Space Radiobiology, Key Laboratory of Heavy Ion Radiation Biology and Medicine, 71200Institute of Modem Physics, Chinese Academy of Sciences, Lanzhou, China.
Xiang WangKey Laboratory of Digestive Disease, Gansu Province, 12426Lanzhou University Second Hospital, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delta-like ligand 4 is a notch ligand that is predominantly expressed in the endothelial tip cells and plays essential roles in the regulation of angiogenesis. In this study, we explored the therapeutic effects of delta-like ligand 4 gene vaccine overexpression on the syngeneic model mouse model of liver cancer and the underlying mechanisms. Mouse hepatocellular carcinoma cell line H22-H8D8 was used to generate subcutaneous syngeneic model liver cancer in Kunming mice, and the effects of recombinant plasmid pVAX1 containing delta-like ligand 4 vaccine on tumor growth was examined. Compared to controls, delta-like ligand 4 vaccination reduced syngeneic model tumor size by 70.31% (from 17.11 ± 9.30 cm

Indexed as

Gene ExpressionAnimalsBiomarkersCancer VaccinesCell Line, TumorDisease Models, AnimalImmunity, CellularImmunity, HumoralImmunotherapyIntracellular Signaling Peptides and ProteinsLiver NeoplasmsMembrane ProteinsMiceSurvival RateTreatment OutcomeTumor BurdenBiomarkersCancer Vaccinesdelta proteinIntracellular Signaling Peptides and ProteinsMembrane ProteinsVaccines, DNAanti-tumor effectdelta-like ligand 4DNA vaccinehepatocellular carcinomaimmune responseimmunotherapy

Identifiers

PMID33191858
PMCPMC7672725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.