ArticleAllergy, asthma & immunology research2021
Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort.
Article in Allergy, asthma & immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The Prevalence of Allergic Rhinitis in Korean Children: Nationwide Surveys in the Periods 1995-2022.Allergy, asthma & immunology research · 2025Article
- Pet Ownership Increases the Exhaled Nitric Oxide and Asthma Severity in Children With Atopic Asthma.Allergy, asthma & immunology research · 2025Article
- Navigating the Asthma Maze in Children Through Trajectories With Allergic Comorbidities.Allergy, asthma & immunology research · 2025Article
- Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study.Allergy, asthma & immunology research · 2025Article
- Artificial intelligence in pediatric allergy research.European journal of pediatrics · 2024Review
- Childhood asthma phenotypes and endotypes: a glance into the mosaic.Molecular and cellular pediatrics · 2023Review
- [Lessons from Korean Childhood Asthma Study Cohort and Needs for Long-term Prospective Study].Jugan geon-gang gwa jilbyeong · 2023Review
- Sex Plays a Multifaceted Role in Asthma Pathogenesis.Biomolecules · 2022Review
- Clinical Experience with Anti-IgE Monoclonal Antibody (Omalizumab) in Pediatric Severe Allergic Asthma-A Romanian Perspective.Children (Basel, Switzerland) · 2021Article
- Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration.Annals of translational medicine · 2021Article
- Implication of Cluster Analysis in Childhood Asthma.Allergy, asthma & immunology research · 2021Article
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Authors and funding
23 authors at 19 institutions in 1 country.
Funding
Abstract
purposeAsthma is a heterogeneous airway disease occurring in children, and it has various clinical phenotypes. A clear differentiation of the clinical phenotypes can provide better asthma management and prediction of asthma prognosis. Little is currently known about asthma phenotypes in Korean children. This study was designed to identify asthma phenotypes in school-aged Korean children.
methodsThis study enrolled 674 children with physician-diagnosed asthma from the Korean childhood Asthma Study (KAS) cohort. The physicians verified the relevant histories of asthma and comorbid diseases, as well as airway lability and hyper-responsiveness from the results of pulmonary function tests and bronchial provocation tests. Questionnaires regarding the participants' baseline characteristics, their environment and self-rating of asthma control were collected at the time of enrollment. Laboratory tests were performed to assess allergy and airway inflammation. Children with asthma were classified by hierarchical cluster analysis.
resultsOf the 674 patients enrolled from the KAS cohort, 447 were included in the cluster analysis. Cluster analysis of these 447 children revealed 4 asthma phenotypes: cluster 1 (n = 216, 48.3%) which was characterized by male-dominant atopic asthma; cluster 2 (n = 79, 17.7%) which was characterized by early-onset atopic asthma with atopic dermatitis; cluster 3 (n = 47, 10.5%) which was characterized by puberty-onset, female-dominant atopic asthma with the low lung function; and cluster 4 (n = 105, 23.5%) which was characterized by early-onset, non-atopic dominant asthma.
conclusionsThe asthma phenotypes among Korean children can be classified into 4 distinct clusters. Long-term follow-up with these phenotypes will be needed to define their prognosis and response to treatment.
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