ReviewMolecular microbiology2021
Plasmodium sporozoites on the move: Switching from cell traversal to productive invasion of hepatocytes.
Review in Molecular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Divergent Autophagy Pathways in Plasmodium: Mechanisms, Functions, and Therapeutic Potential.Molecular microbiology · 2026Review
- A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites.PLoS pathogens · 2026Article
- The case for exploring innate memory in Plasmodium infection.Current opinion in microbiology · 2026Review
- Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of Plasmodium falciparum sporozoite-host interactions.PLoS genetics · 2026Article
- The CLAMP-Linked Invasion Protein (CLIP) plays an essential role inbioRxiv : the preprint server for biology · 2026Article
- Malaria vaccines: Current developments and immunological insights.New microbes and new infections · 2025Article
- Targeting Bottlenecks in Malaria Transmission: Antibody-Epitope Descriptions Guide the Design of Next-Generation Biomedical Interventions.Immunological reviews · 2025Review
- Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei.Scientific reports · 2025Article
- Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms.Frontiers in cellular and infection microbiology · 2025Review
- A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites.Nature communications · 2024Article
- In-silico analysis of potent Mosquirix vaccine adjuvant leads.Journal, genetic engineering & biotechnology · 2023Article
- Current advances in nanodrug delivery systems for malaria prevention and treatment.Discover nano · 2023Review
- The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites.PLoS pathogens · 2023Article
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- Autophagy in protists and their hosts: When, how and why?Autophagy reports · 2023Article
- The roles of COX-2 in protozoan infection.Frontiers in immunology · 2023Review
- The origins, isolation, and biological characterization of rodent malaria parasites.Parasitology international · 2022Review
- Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- AiScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites migrate through the dermis, enter the bloodstream, and rapidly traffic to the liver. They cross the liver sinusoidal barrier and traverse several hepatocytes before switching to productive invasion of a final one for replication inside a parasitophorous vacuole. Cell traversal and productive invasion are functionally independent processes that require proteins secreted from specialized secretory organelles known as micronemes. In this review, we summarize the current understanding of how sporozoites traverse through cells and productively invade hepatocytes, and discuss the role of environmental sensing in switching from a migratory to an invasive state. We propose that timely controlled secretion of distinct microneme subsets could play a key role in successful migration and infection of hepatocytes. A better understanding of these essential biological features of the Plasmodium sporozoite may contribute to the development of new strategies to fight against the very first and asymptomatic stage of malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.