Evidence map›Paper›PMID 33191466›Full record

ArticleGeroScience2021

Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Melod Mehdipour, Taha Mehdipour, Colin M Skinner, Nathan Wong, Chao Liu, Chia-Chien Chen, Ok Hee Jeon, Yi Zuo, Michael J Conboy, Irina M Conboy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Research progress on blood therapy for anti-aging.Journal of advanced research · 2026
    Review
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  10. Allostery in Biomolecular Condensates.Journal of molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Melod MehdipourDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Taha MehdipourDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Colin M SkinnerDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Nathan WongDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Chao LiuDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Chia-Chien ChenDepartment of Molecular and Cellular Biology and QB3, UCSC, Santa Cruz, CA, USA.
Ok Hee JeonBuck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA, USA.
Yi ZuoDepartment of Molecular and Cellular Biology and QB3, UCSC, Santa Cruz, CA, USA.
Michael J ConboyDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA.
Irina M ConboyDepartment of Bioengineering and QB3, UC Berkeley, Berkeley, CA, USA. iconboy@berkeley.edu.
University of California, Berkeley · USUniversity of California, Santa Cruz · USBuck Institute for Research on Aging · US

Funding

Stem Cell Engineering Training ProgramT32GM098218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, SCHAFFER, DAVID V · 2011 to 2020
$1.8M
New Generation Blood Exchange Devices for Enhancing Tissue Regeneration and HealthR01HL139605 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ARAN, KIANA, CONBOY, IRINA M · 2018 to 2021
$1.6M
Defined pharmacology for multi-tissue rejuvenation acting through youthful normalization of p16R56AG058819 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M · 2018 to 2018
$381k
NHLBI NIH HHS R01 HL139605NIA NIH HHS R56 AG058819NIGMS NIH HHS T32 GM098218
6 · The paper itself

Abstract

Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) that resets signaling milieu to a pro-regenerative state through dilution of old plasma, enhanced the health and repair of the muscle and liver, and promoted better hippocampal neurogenesis in 2-year-old mice (Mehdipour et al., Aging 12:8790-8819, 2020). Here we expand the rejuvenative phenotypes of NBE, focusing on the brain. Namely, our results demonstrate that old mice perform much better in novel object and novel texture (whisker discrimination) tests after a single NBE, which is accompanied by reduced neuroinflammation (less-activated CD68

Indexed as

CognitionRejuvenationAgingAnimalsMiceNeurogenesisPlasmaMemory and CognitionNeuroinflammationNeutral blood exchangePlasma dilutionRejuvenationSenolytics

Identifiers

PMID33191466
PMCPMC8050203
OpenAlexW3103505494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.