Evidence map›Paper›PMID 33191326›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma.

Takahiro Kametani, Yuichiro Otani, Toshikazu Ohigashi, Tadahiko Kubo, Tomohiko Sakuda, Daisuke Furuta, Yayoiko Ito, Yuya Shigenobu, Masaki Kakimoto, Akihiro Kawahara and 6 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Takahiro KametaniDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Yuichiro OtaniDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Toshikazu OhigashiDepartment of Pharmaceutical Services, Hiroshima University Hospital, Japan.
Tadahiko KuboDepartment of Orthopaedic Surgery, Hiroshima University, Graduate School of Biomedical & Health Sciences, Japan.
Tomohiko SakudaDepartment of Orthopaedic Surgery, Hiroshima University, Graduate School of Biomedical & Health Sciences, Japan.
Daisuke FurutaDepartment of Orthopaedic Surgery, Hiroshima University, Graduate School of Biomedical & Health Sciences, Japan.
Yayoiko ItoDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Yuya ShigenobuDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Masaki KakimotoDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Akihiro KawaharaDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Yuka KikuchiDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Tomoki KobayashiDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Daisuke MiyamoriDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Nobusuke KishikawaDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Keishi KannoDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Masanori ItoDepartment of General Internal Medicine, Hiroshima University Hospital, Japan.
Hiroshima University Hospital · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient's underlying diseases or therapeutic pharmacological backgrounds.

Indexed as

AortitisChondrosarcomaExanthemaLung InjuryGranulocyte Colony-Stimulating FactorHumansNeoplasm Recurrence, LocalSplenomegalyGranulocyte Colony-Stimulating FactoraortitisG-CSFpegfilgrastimsarcoma

Identifiers

PMID33191326
PMCPMC8112981
OpenAlexW3101143705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.