Evidence map›Paper›PMID 33191277›Full record

ArticleThe Journal of rheumatology2021

Relationship Between Depression and Disease Activity in United States Veterans With Early Rheumatoid Arthritis Receiving Methotrexate.

Alan M Rathbun, Bryant R England, Ted R Mikuls, Alice S Ryan, Jennifer L Barton, Michelle D Shardell, Marc C Hochberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alan M RathbunA.M. Rathbun, PhD, MPH, Department of Epidemiology and Public Health, and Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland; arathbun@som.umaryland.edu.
Bryant R EnglandB.R. England, MD, PhD, T.R. Mikuls, MD, MSPH, VA Nebraska-Western Iowa Health Care System, and Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska.ORCID 0000-0002-9649-3588
Ted R MikulsB.R. England, MD, PhD, T.R. Mikuls, MD, MSPH, VA Nebraska-Western Iowa Health Care System, and Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska.
Alice S RyanA.S. Ryan, PhD, Department of Medicine, University of Maryland Baltimore, School of Medicine, and VA Maryland Health Care System, Baltimore, Maryland.
Jennifer L BartonJ.L. Barton, MD, MCR, VA Portland Health Care System, and Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, Oregon.
Michelle D ShardellM.D. Shardell, PhD, Department of Epidemiology and Public Health, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland.
Marc C HochbergM.C.Hochberg, MD, MPH, Department of Epidemiology and Public Health, and Department of Medicine, University of Maryland Baltimore, School of Medicine, and VA Maryland Health Care System, Baltimore, Maryland, USA.
University of Maryland, Baltimore · USVA Nebraska Western Iowa Health Care System · USOregon Health & Science University · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
Goal concordance in rheumatoid arthritis in diverse populationsK23AR064372 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARTON, JENNIFER L · 2015 to 2019
$805k
A Feasibility and Pilot Study of Combined Treatment Protocol using Aerobic Exercise and Duloxetine in Older Adults with Symptomatic Knee Osteoarthritis and Comorbid DepressionK01AG064041 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI RATHBUN, ALAN MICHAEL · 2019 to 2023
$619k
Pathogenic Role of Malondialdehyde-Acetaldehyde Adducts in Rheumatoid ArthritisI01BX004660 · VA · OMAHA VA MEDICAL CENTER · PI MIKULS, TED RICHARD · 2020 to 2023
–
Progressive Activity-Based Rehabilitation in Veteran Cancer Survivors with Chronic PainI21RX002870 · VA · BALTIMORE VA MEDICAL CENTER · PI RYAN, ALICE S. · 2019 to 2022
–
Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected VeteransI01RX002790 · VA · SALEM VA MEDICAL CENTER · PI MARCONI, VINCENT CHARLES, OURSLER, KRISANN K · 2020 to 2023
–
Resistive Training Combined with Nutritional Therapy after StrokeI01RX001461 · VA · BALTIMORE VA MEDICAL CENTER · PI IVEY, FREDERICK M., RYAN, ALICE S. · 2015 to 2021
–
BLRD VA I01 BX004660NIAMS NIH HHS K23 AR064372NIA NIH HHS K01 AG064041NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG048069NIDDK NIH HHS P30 DK072488NIGMS NIH HHS U54 GM115458RRD VA I01 RX001461RRD VA I01 RX002790RRD VA I21 RX002870RRD VA IK6 RX003977
6 · The paper itself

Abstract

objectiveDepression is common in patients with rheumatoid arthritis (RA), exacerbates disease activity, and may decrease response to first-line disease-modifying antirheumatic drugs. This study aimed to determine if depression affects disease activity among veterans with early RA prescribed methotrexate (MTX).

methodsParticipants included veterans enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry with early RA (onset < 2 yrs) prescribed MTX. Depression was assessed at enrollment using the International Classification of Diseases, 9th revision codes (296.2-296.39, 300.4, 311). Disease activity was measured using the Disease Activity Score in 28 joints (DAS28) and other core measures of RA disease activity. Propensity score weights were used to adjust depressed (n = 48) and nondepressed (n = 220) patients on baseline confounders within imputed datasets. Weighted estimating equations were used to assess standardized mean differences in disease activity between depressed and nondepressed patients at 6-month, 1-year, and 2-year follow-ups.

resultsThe analytic sample was composed of 268 veterans with early RA prescribed MTX who were predominantly male (n = 239, 89.2%) and older (62.7 yrs, SD 10.6) than patients with RA in the general population. Adjusted estimates indicated that depression was associated with significantly higher DAS28 at 6 months (β 0.35, 95% CI 0.01-0.68) but not at the 1- or 2-year follow-up. Also, depression was associated with significantly worse pain at 6 months (β 0.39, 95% CI 0.04-0.73) and 1 year (β 0.40, 95% CI 0.04-0.75).

conclusionIn early RA, depression is associated with greater short-term disease activity during MTX treatment, as well as more persistent and severe pain.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidVeteransDepressionDrug Therapy, CombinationHumansMaleMethotrexateSeverity of Illness IndexTreatment OutcomeUnited StatesAntirheumatic AgentsMethotrexatedepressiondisease activitydisease-modifying antirheumatic drugsrheumatoid arthritis

Identifiers

PMID33191277
PMCPMC8121898
OpenAlexW3105801652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.