Evidence map›Paper›PMID 33191186›Full record

ArticleThe journal of sexual medicine2021

COVID-19 Infection in Men on Testosterone Replacement Therapy.

Amarnath Rambhatla, Chandler J Bronkema, Nicholas Corsi, Jacob Keeley, Akshay Sood, Ziad Affas, Ali A Dabaja, Craig G Rogers, Stephen A Liroff, Firas Abdollah

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of sexual medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
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  6. SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023
    Review
  7. Review
  8. Testosterone and Covid-19: An update.Reviews in medical virology · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Amarnath RambhatlaDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA. Electronic address: Arambha1@hfhs.org.
Chandler J BronkemaSchool of Medicine, Wayne State University, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Nicholas CorsiSchool of Medicine, Wayne State University, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Jacob KeeleyCenter for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Akshay SoodDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Ziad AffasCenter for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Ali A DabajaDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.
Craig G RogersDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.
Stephen A LiroffDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.
Firas AbdollahDepartment of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA; Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA.
Henry Ford Health System · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMen who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects.

aimWe sought to determine if testosterone replacement therapy (TRT) is associated with worse clinical outcomes.

methodsThrough a retrospective chart review, we identified 32 men diagnosed with COVID-19 and on TRT. They were propensity score matched to 63 men diagnosed with COVID-19 and not on TRT. Data regarding comorbidities and endpoints such as hospital admission, intensive care unit admission, ventilator utilization, thromboembolic events, and death were extracted. Chi-square and Kruskal-Wallis tests examined differences in categorical and continuous variables, respectively. Logistic regression analysis tested the relationship between TRT status and the study endpoints.

resultsThere were no statistically significant differences between the 2 groups, and TRT was not a predictor of any of the endpoints on multivariate analysis.

conclusionThese results suggest that TRT is not associated with a worse clinical outcome in men diagnosed with COVID-19. Rambhatla A, Bronkema CJ, Corsi N, et al. COVID-19 Infection in Men on Testosterone Replacement Therapy. J Sex Med 2021;18:215-218.

Indexed as

COVID-19HypogonadismHormone Replacement TherapyHumansMaleRetrospective StudiesSARS-CoV-2TestosteroneTestosteroneAndrogensCOVID-19HypogonadismSARS-CoV-2TestosteroneTestosterone Replacement TherapyVenous Thromboembolism

Identifiers

PMID33191186
PMCPMC7546237
OpenAlexW3092066029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.