Evidence map›Paper›PMID 33191004›Full record

ArticleJournal of substance abuse treatment2021

Rapid transitional response to the COVID-19 pandemic by opioid agonist treatment programs in Ukraine.

Anna Meteliuk, Samy J Galvez de Leon, Lynn M Madden, Iryna Pykalo, Tatiana Fomenko, Myroslava Filippovych, Scott O Farnum, Sergii Dvoryak, Zahedul M Islam, Frederick L Altice

Open access · hybridAbstract read
In one paragraph

Article in Journal of substance abuse treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anna MeteliukICF 'Alliance for Public Health', Kyiv, Ukraine.
Samy J Galvez de LeonYale School of Medicine, Section of Infectious Diseases, New Haven, CT, United States.
Lynn M MaddenYale School of Medicine, Section of Infectious Diseases, New Haven, CT, United States; APT Foundation, New Haven, CT, United States.
Iryna PykaloUkrainian Institute on Public Health Policy, Kyiv, Ukraine.
Tatiana FomenkoICF 'Alliance for Public Health', Kyiv, Ukraine.
Myroslava FilippovychUkrainian Institute on Public Health Policy, Kyiv, Ukraine.
Scott O FarnumAPT Foundation, New Haven, CT, United States.
Sergii DvoryakUkrainian Institute on Public Health Policy, Kyiv, Ukraine.
Zahedul M IslamICF 'Alliance for Public Health', Kyiv, Ukraine.
Frederick L AlticeYale School of Medicine, Section of Infectious Diseases, New Haven, CT, United States; APT Foundation, New Haven, CT, United States; Yale School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, CT, United States. Electronic address: frederick.altice@yale.edu.
Alliance for Public Health · UAAPT Foundation · USUkrainian Institute of Public Health Policy · UAYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Integrating Addiction Treatment and HIV Services into Primary Care Clinics in UkraineR01DA043125 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2016 to 2021
$4.4M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA033679NIDA NIH HHS R01 DA043125
6 · The paper itself

Abstract

On March 16, 2020, Ukraine's Ministry of Health issued nonspecific interim guidance to continue enrolling patients in opioid agonist therapies (OAT) and transition existing patients to take-home dosing to reduce community COVID-19 transmission. Though the number of OAT patients increased modestly, the proportion receiving take-home dosing increased from 57.5% to 82.2%, which translates on average to 963,952 fewer clinic interactions annually (range: 728,652-1,016,895) and potentially 80,329 (range: 60,721-84,741) fewer hours of in-person clinical encounters. During the transition, narcologists (addiction specialists) expressed concerns about overdoses, the guidance contradicting existing legislation, and patient dropout, either from incarceration or inadequate public transportation. Though clinicians did observe some overdoses, short-term overall mortality remained similar to the previous year. As the country relaxes the interim guidance, we do not know to what extent governmental guidance or clinical practice will change to adopt the new guidance permanently or revert to pre-guidance regulations. Some future considerations that have come from COVID-19 are should dosing schedules continue to be flexible, should clinicians adopt telehealth, and should there be more overdose education and naloxone distribution? OAT delivery has improved and become more efficient, but clinicians should plan long-term should COVID-19 return in the near future. If the new efficiencies are maintained, it will free the workforce to further scale up OAT.

Indexed as

Opiate Substitution TreatmentAnalgesics, OpioidBuprenorphineCOVID-19Drug OverdoseHumansMethadoneOpioid-Related DisordersPatient DropoutsTelemedicineUkraineAnalgesics, OpioidBuprenorphineMethadoneBuprenorphineCOVID-19MethadoneOpioid agonist therapiesPolicyUkraine

Identifiers

PMID33191004
PMCPMC7769928
OpenAlexW3092563374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.