Evidence map›Paper›PMID 33190663›Full record

ArticleEpidemiology and infection2020

Factors associated with typical enteropathogenic

K Fagerli, R Omore, S Kim, J B Ochieng, T L Ayers, J Juma, T H Farag, D Nasrin, S Panchalingam, R M Robins-Browne and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

K FagerliNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-7471-6317
R OmoreKenya Medical Research Institute, Kisumu, Kenya.
S KimNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J B OchiengKenya Medical Research Institute, Kisumu, Kenya.
T L AyersNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J JumaKenya Medical Research Institute, Kisumu, Kenya.
T H FaragCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
D NasrinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
S PanchalingamCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
R M Robins-BrownePeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
J P NataroCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
K L KotloffCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
M M LevineCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
J OundoKenya Medical Research Institute, Kisumu, Kenya.
M B ParsonsNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
K F LasersonCenter for Global Health, Centers for Disease Control and Prevention, Nairobi, Kenya.
E D MintzNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
R F BreimanEmory Global Health Institute, Emory University, Atlanta, GA, USA.
C E O'ReillyNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37-3.17), and convulsions (aOR 2.83, 95% CI 1.12-7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3-3.6) and wasted (OR 2.5, 95% CI 1.3-4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47-5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.

Indexed as

Case-Control StudiesChild Nutrition DisordersChild, PreschoolDiarrheaEnteropathogenic Escherichia coliEscherichia coli InfectionsFemaleHumansInfantInfant, NewbornKenyaMaleDiarrhoeaEscherichia coli (E. coli)water-borne infections

Identifiers

PMID33190663
PMCPMC7770376

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.