Evidence map›Paper›PMID 33190655›Full record

ArticleThe Journal of laryngology and otology2020

Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia.

L A Vaira, C Hopkins, A Sandison, A Manca, N Machouchas, D Turilli, J R Lechien, M R Barillari, G Salzano, A Cossu and 2 more

Abstract readCase Reports
In one paragraph

Article in The Journal of laryngology and otology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
  7. Article
  8. Topical Anesthesia and Olfactory Capability: A Pilot Study.Laryngoscope investigative otolaryngology · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Nasal sprays for treating COVID-19: a scientific note.Pharmacological reports : PR · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L A VairaMaxillofacial Surgery Operative Unit, University Hospital of Sassari, Italy.
C HopkinsDepartment of ENT, King's College, London, UK.
A SandisonDepartment of Histopathology, Charing Cross Hospital and Imperial College Healthcare NHS Trust, London, UK.
A MancaHistopathology Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
N MachouchasOtorhinolaryngology Operative Unit, University Hospital of Sassari, Italy.
D TurilliRadiology Operative Unit, University Hospital of Sassari, Italy.
J R LechienCOVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies ('YO-IFOS'), Belgium.
M R BarillariDepartment of Mental and Physical Health and Preventive Medicine, Luigi Vanvitelli University, Naples, Italy.
G SalzanoMaxillofacial Surgery Unit, University Hospital of Naples 'Federico II', Italy.
A CossuHistopathology Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
S SaussezCOVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies ('YO-IFOS'), Belgium.
G De RiuMaxillofacial Surgery Operative Unit, University Hospital of Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. CASE REPORT: This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2.

conclusionThe biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.

Indexed as

AnosmiaCortisoneCOVID-19FemaleHumansMagnetic Resonance ImagingMiddle AgedOlfaction DisordersOlfactory BulbOlfactory MucosaSARS-CoV-2Treatment OutcomeCortisoneAnosmiaCoronavirusEtiologyOlfaction DisordersPathologySARS-CoVSmell

Identifiers

PMID33190655
PMCPMC7729153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.