Evidence map›Paper›PMID 33190654›Full record

ArticleParasitology2021

Effectiveness of doxycycline for the treatment of zoonotic cutaneous leishmaniasis

Iuliia K Akulinina, Iza A Berechikidze, Svetlana N Larina, Tatyana V Sakharova, Tatyana Yu Degtyarevskaya, Marco Romanelli

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05708625 (Efficacy of Intralesional Voriconazole Versus Intralesional Cryotherapy Versus Intralesional Sodium Stibogluconate Versus Oral Doxycycline in the Treatment of Acute Cutaneous Leishmaniasis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708625 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

Efficacy of Intralesional Voriconazole Versus Intralesional Cryotherapy Versus Intralesional Sodium Stibogluconate Versus Oral Doxycycline in the Treatment of Acute Cutaneous Leishmaniasis

TypeinterventionalSponsorZagazig UniversityRan2022 to 2024Enrolled136ConditionsLeishmaniasis, CutaneousArmsIntralesional Sodium stibogluconate, Intralesional Cryotherapy, Intralesional Voriconazole, Oral doxycycline
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Iuliia K AkulininaDepartment of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.ORCID 0000-0002-6732-1197
Iza A BerechikidzeDepartment of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.
Svetlana N LarinaDepartment of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.
Tatyana V SakharovaDepartment of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.
Tatyana Yu DegtyarevskayaDepartment of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Molodogvardeiskaya str., 34-263, Moscow121351, Russian Federation.
Marco RomanelliDepartment of Dermatology, University of Pisa, Via Roma, 67, Pisa56126, Italy.
Sechenov University · RUUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are available data on in vivo studies of monotherapy of zoonotic cutaneous leishmaniasis with some antibacterial drugs (doxycycline) and their comparison with meglumine antimoniate (glucantime). We used golden Syrian hamsters as a laboratory model. Experimental groups were formed, each of which was treated with one of the tested drugs. Infection of animals was carried out with Leishmania major promastigotes. We selected highly virulent strains of L. major culture isolated from human ulcers or rodents. Meglumine antimoniate monotherapy and doxycycline monotherapy are quite effective and do not differ by the 30th day of their use in such indicators as the average degree of local damage and the average number of Leishmania in the lesions. The main differences were recorded in terms of average body weight gain and average clinical recovery in favour of doxycycline. Leishmania in the lesion on the 60th day were completely absent in treatment with doxycycline. The experiment proved the effectiveness of doxycycline monotherapy: Leishmania in the lesions were absolutely absent by the end of the treatment.

Indexed as

AnimalsAntiprotozoal AgentsDisease Models, AnimalDoxycyclineLeishmaniasis, CutaneousMesocricetusZoonosesAntiprotozoal AgentsDoxycyclineAntibioticsdoxycyclineglucantimemeglumine antimoniatezoonotic cutaneous leishmaniasis

Identifiers

PMID33190654
PMCPMC11010172
OpenAlexW3102321942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.