ArticleParasitology2021
Diagnostic comparison of stool exam and point-of-care circulating cathodic antigen (POC-CCA) test for schistosomiasis mansoni diagnosis in a high endemicity area in northeastern Brazil.
Article in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Accuracy of diagnostic strategies for detecting Schistosoma mansoni infection in Brazil: A systematic review and meta-analysis.Revista da Sociedade Brasileira de Medicina Tropical · 2026Pooled it
- Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil.International journal for parasitology. Drugs and drug resistance · 2025Trial
- Evaluating short-term changes in helminth burdens using sequential community-based surveys in Rwanda.Scientific reports · 2026Article
- Prevalence of neglected tropical diseases in rural productive villages of the São Francisco River Integration Project in Ceará: cross-sectional study, 2020.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Reduced plasma levels of GM-CSF is a common feature ofFrontiers in immunology · 2025Article
- Home-Made Lateral Flow Test Strip Versus POC-CCA Assay for Detection of Active Schistosomiasis in Egypt.Acta parasitologica · 2024Article
- Article
- Evaluation of the epidemiological situation of intestinal schistosomiasis using the POC-CCA parasite antigen test and the Kato-Katz egg count test in school-age children in endemic villages in western Côte d'Ivoire.Parasite (Paris, France) · 2024Article
- Evaluation of the Urine POC-CCA Test Accuracy in the Detection ofJournal of tropical medicine · 2024Review
- Challenges to Schistosomiasis Control Program in Brazil: setbacks in the control program and critical analysis of the disease notification.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Reliability of point-of-care circulating cathodic antigen assay for diagnosing schistosomiasis mansoni in urine samples from an endemic area of Brazil after one year of storage at -20 degrees Celsius.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Undernutrition, food insecurity, and leprosy in North Gondar Zone, Ethiopia: A case-control study to identify infection risk factors associated with poverty.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the performance of the point-of-care circulating cathodic antigen (POC-CCA) test in a highly endemic area in Brazil, comparing it to the Kato-Katz (KK) technique for sensitivity, specificity and the intensity of the reaction of the test in relation to the parasitic load. The community in Sergipe, Brazil, participated in the study, providing three stool samples, one of urine (POC-CCA) and fingers tick blood sample was tested by enzyme-linked immunosorbent assay (ELISA). Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, kappa coefficient and Spearman's correlation were calculated for the POC-CCA test using the KK as the reference. The prevalence of schistosomiasis by KK testing was 48.82%; POC-CCA (t+) 66.14%; POC-CCA (t-) 45.24%. ELISA results showed 100% agreement in individuals with high and moderate eggs per gram (EPG). POC-CCA presented good diagnostic performance in individuals with medium and high EPG, but there were a high number of false negatives in individuals with low intensity infections. As observed, POC-CCA-filter test improves accuracy and sensitivity compared to a conventional test.
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