Evidence map›Paper›PMID 33190340›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2021

Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France.

Ricardo Carbajal, Mathie Lorrot, Yael Levy, Emmanuel Grimprel, Thibault Lecarpentier, Sebastien Heritier, Judith Faivre, Aurélie Schnuriger, Pauline Parisot, Eléonore Blondiaux and 6 more

Abstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Oral manifestations of multisystemic inflammatory syndrome in children (MIS-C) and Kawasaki disease associated to COVID-19: A systematic review.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2022
    Pooled it
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  12. Post-COVID-19 severe neutropenia.Pediatric blood & cancer · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Ricardo CarbajalPediatric Emergency Department, APHP Hôpital Armand Trousseau - Sorbonne Université, INSERM UMR1153, Paris, France.ORCID https://orcid.org/0000-0002-3616-1549
Mathie LorrotGeneral Pediatrics Department, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Yael LevyPediatric Intensive Care Unit, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Emmanuel GrimprelGeneral Pediatrics Department, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Thibault LecarpentierPediatric Emergency Department, APHP Hôpital Armand Trousseau - Sorbonne Université, INSERM UMR1153, Paris, France.
Sebastien HeritierPediatric Hematology and Oncology Department, APHP Hôpital Armand Trousseau, Paris, France.
Judith FaivrePediatric Anesthesiology Department, APHP Hôpital Armand Trousseau, Paris, France.
Aurélie SchnurigerVirology Department, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Pauline ParisotPediatric Cardiology Unit, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Eléonore BlondiauxPediatric Imaging Department, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Solene LoschiPediatric Emergency Department, APHP Hôpital Armand Trousseau - Sorbonne Université, INSERM UMR1153, Paris, France.
Simon RivièrePediatric Emergency Department, APHP Hôpital Armand Trousseau - Sorbonne Université, INSERM UMR1153, Paris, France.
Julia GuilbertPediatric Intensive Care Unit, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Anne-Sophie RomainGeneral Pediatrics Department, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Pierre-Louis LegerPediatric Intensive Care Unit, APHP Hôpital Armand Trousseau - Sorbonne Université, Paris, France.
Romain GuedjPediatric Emergency Department, APHP Hôpital Armand Trousseau - Sorbonne Université, INSERM UMR1153, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study determined the influence of the COVID-19 pandemic on the occurrence of multisystem inflammatory syndrome in children (MIS-C) and compared the main characteristics of MIS-C and Kawasaki disease (KD).

methodsWe included patients aged up to 18 years of age who were diagnosed with MIS-C or KD in a paediatric university hospital in Paris from 1 January 2018 to 15 July 2020. Clinical, laboratory and imaging characteristics were compared, and new French COVID-19 cases were correlated with MIS-C cases in our hospital.

resultsThere were seven children with MIS-C, from 6 months to 12 years of age, who were all positive for the virus that causes COVID-19, and 40 virus-negative children with KD. Their respective characteristics were as follows: under 5 years of age (14.3% vs. 85.0%), paediatric intensive care unit admission (100% vs. 10.0%), abdominal pain (71.4% vs. 12.5%), myocardial dysfunction (85.7% vs. 5.0%), shock syndrome (85.7% vs. 2.5%) and mean and standard deviation C-reactive protein (339 ± 131 vs. 153 ± 87). There was a strong lagged correlation between the rise and fall in MIS-C patients and COVID-19 cases.

conclusionThe rise and fall of COVID-19 first wave mirrored the MIS-C cases. There were important differences between MIS-C and KD.

Indexed as

AdolescentChildChild, PreschoolCOVID-19FemaleFranceHospitalizationHospitals, PediatricHospitals, UniversityHumansInfantMaleMucocutaneous Lymph Node SyndromeRetrospective StudiesSystemic Inflammatory Response SyndromeCOVID-19Kawasaki diseasemultisystem inflammatory syndromepandemicPIMS

Identifiers

PMID33190340
PMCPMC7753535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.